Publications by authors named "Jose Luis Gonzalez Llerena"
Recent insights into the influence of nutrition on immune system components have driven the development of dietary strategies targeting the prevention and management of major metabolic-inflammatory diseases. This review summarizes the bidirectional relationship between nutrition and immunocompetence, beginning with an overview of immune system components and their functions. It examines the effects of nutritional status, dietary patterns, and food bioactives on systemic inflammation, immune cell populations, and lymphoid tissues, as well as their associations with infectious and chronic disease pathogenesis.
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- Cordycepin, an adenosine analog, differs from adenosine by lacking a hydroxyl group at the 3' position, which allows it to be transformed into cordycepin triphosphate in certain tissues.
- This study utilized chemoinformatics, bioinformatics, and molecular dynamics simulations to compare cordycepin and its derivatives with natural purine metabolites, hypothesizing that cordycepin triphosphate can bind to adenylate cyclase similarly to ATP.
- The findings suggest that cordycepin triphosphate may inhibit cAMP production by acting as a pseudo-ATP, potentially enhancing antitumor immunity and influencing the behavior of cells in the tumor microenvironment
Antidiabetic Drugs and their Potential Use in COVID-19: A Mechanistic Approach.
Endocr Metab Immune Disord Drug Targets
August 2023
Many therapies have been developed against COVID-19 since it first appeared in December 2019. Antivirals, antimalarials, cephalosporins, colchicine, anticoagulants, and corticosteroids, among others, have been evaluated as protecting agents against antibacterial complications due to their anti-inflammatory and immunomodulatory effects against thrombosis and cell death caused by infection with SARS-CoV-2. Nevertheless, the overall balance in their application has not been found to be satisfactory.
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