Biochim Biophys Acta Biomembr
June 2023
A new decyl chain [-(CH)CH] riboflavin conjugate has been synthesized and investigated. A nucleophilic substitution (S2) reaction was used for coupling the alkyl chain to riboflavin (Rf), a model natural photosensitizer. As expected, the alkylated compound (decyl-Rf) is significantly more lipophilic than its precursor and efficiently intercalates within phospholipid bilayers, increasing its fluorescence quantum yield.
View Article and Find Full Text PDFThe physical properties of lipid membranes depend on their lipid composition. Photosensitized singlet oxygen (O) provides a handle to spatiotemporally control the generation of lipid hydroperoxides via the reaction, enabling fundamental studies on membrane dynamics in response to chemical composition changes. Critical to relating the physical properties of the lipid membrane to hydroperoxide formation is the availability of a sensitive reporter to quantify the arrival of O.
View Article and Find Full Text PDFHere, we provide mechanistic insight to the photocleavage of a compound in the folate family, namely pteroic acid. A bis-decyl chain derivative of pteroic acid was synthesized, structurally characterized and photochemically investigated. We showed that, like folic acid, pteroic acid and the decylated derivative undergo a photocleavage reaction in the presence of H O, while no reaction was observed in methanol solution.
View Article and Find Full Text PDFThe authors present a surgical approach to type III and IV Crawford aneurysms that does not need total aortic clamping, which allows the more objective prevention of direct ischemic damage, as well as its exclusion by the endoprosthesis implantation, shunting the flow to the synthetic graft.
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