Chronic liver disease-associated severe thrombocytopenia in Spain: Results from a retrospective study using machine learning and natural language processing.

Background: Patients with chronic liver disease (CLD) often develop thrombocytopenia (TCP) as a complication. Severe TCP (platelet count<50×10/L) can increase morbidity and complicate CLD management, increasing bleeding risk during invasive procedures.

Objectives: To describe the real-world scenario of CLD-associated severe TCP patients' clinical characteristics.

Faecal Microbiota Transplantation is a simple, effective and safe treatment in the management of C. difficile infection in daily clinical practice.

Introduction: Faecal microbiota transplantation (FMT) is a treatment supported by wide scientific evidence and proved to be very effective in the management of Clostridioides difficile infection (CDI). The objective of this study is to analyze its effectiveness and safety in a real clinical practice setting.

Methods: Retrospective, single-center and descriptive observational study in which all FMT performed between May 2016 and December 2020 were included.

Patient journey of individuals tested for HCV in Spain: LiverTAI, a retrospective analysis of EHRs through natural language processing.

Objectives: Limited screening and delays in diagnosis and linkage-to-care are barriers for hepatitis C virus (HCV) elimination. The LiverTAI study focused on patients tested for HCV using AI technologies to describe their demographic and clinical characteristics and pre-testing patient journeys, reflecting clinical practice in hospitals.

Patients And Methods: LiverTAI is a retrospective, secondary analysis of electronic health records (EHRs) from 6 tertiary Spanish hospitals, extracting unstructured clinical data using natural language processing (NLP) EHRead® technology.

Inverted Meckel's diverticulum diagnosed using capsule endoscopy: A case report.

Background: Meckel's diverticulum is a common asymptomatic congenital gastrointestinal anomaly. However, its presentation as an inverted Meckel's diverticulum is a rare complication, of which few cases have been reported in the literature.

Case Summary: Here, we report the case of a 33-year-old man with iron deficiency anemia without manifestation of gastrointestinal bleeding.

Non-malignant portal vein thrombosis in a cohort of cirrhotic patients: Incidence and risk factors.

Aim: Non-malignant portal vein thrombosis (PVT) is a complication of liver cirrhosis. The aim of this study was to evaluate the annual incidence of PVT and related risk factors.

Methods: We retrospectively reviewed clinical, laboratory, and radiological data collected prospectively from September 2016 to September 2017.

The Screening Guidelines for Hepatitis C Virus Infection as a milestone in the path towards hepatitis C virus elimination.

The publication of the Screening Guidelines for Hepatitis C Virus Infection represents a significant milestone in the path towards eliminating this infectious condition. As early as 2015, the National Health System Plan for Tackling Hepatits C (Plan estratégico para el abordaje de la hepatitis C - PEAHC) pointed out the need to define a screening policy. The Health Ministry has managed to bring together all the actors involved, and to create a technical document that represents a benchmark in the definition of the actions needed to identify and bring treatment closer to a significant number of patients diagnosed with hepatitis C who remain untreated.

Estimation of visceral fat is useful for the diagnosis of significant fibrosis in patients with non-alcoholic fatty liver disease.

Background: Obesity is a risk factor for non-alcoholic fatty liver disease (NAFLD), although obese patients with NAFLD do not always develop significant fibrosis. The distribution of body fat could predict the risk of NAFLD progression.

Aim: To investigate the role of bioelectrical impedance-estimated visceral fat (VF) in assessing NAFLD severity.

Management of chronic liver disease-associated severe thrombocytopenia in Spain: a view from the experts.

Background: chronic liver disease (CLD) patients often present thrombocytopenia (TCP) and when severe, it may prevent them from undergoing necessary invasive procedures due to an increased bleeding risk. The lack of scientific evidence makes it impossible to determine key aspects of the current management and associated healthcare burden of these patients in Spain.

Purpose: to gain insight into the current situation of patients with CLD-associated severe TCP undergoing invasive procedures in Spain, based on the experience of clinical experts.

Principles for implementing a population screening strategy for hepatitis C in Spain.

Background: hepatitis C, besides health impairment, results in significant loss of productivity and diminished quality of life, and noticeably contributes to health expenditure increases. Because of all this, the Spanish Ministry of Health (Ministerio de Sanidad, Consumo y Bienestar Social - MSCBS) implemented in 2015 a strategic plan for managing hepatitis C (Plan Estratégico para el Abordaje de la Hepatitis C - PEAHC) within the National Health System. However, the PEAHC includes no screening plan.

Definition of the profiles of hepatitis C virus patients based on the identification of risky practices in Spain.

The absolute number of patients infected with the hepatitis C virus and its prevalence in Spain according to risk practices are not precise. The objective of the study was to estimate the current direct-action antiviral candidates, according to risky practices. The exposed population was determined according to each risky practice and age, based on the data obtained in two epidemiological studies and other bibliographic sources.

Diagnosis of hepatitis C virus infection in Spain: An opportunity to improve.

Background: Reflex testing of antibodies and viral load in the same sample for diagnosing hepatitis C virus infection speeds up access to treatment. However, how hepatitis C is diagnosed in Spanish hospitals is unknown.

Objective: To describe the available resources and procedures for the diagnosis of hepatitis C virus infection in Spain.

The efficiency of several one-step testing strategies for the diagnosis of hepatitis C.

Background: implementing one-step strategies for hepatitis C diagnosis would help shorten the time to treatment access. Thus avoiding disease progression and complications, while facilitating hepatitis C virus (HCV) elimination.

Objective: to assess the validity and certainty of potential one-step strategies for the diagnosis of HCV infection and their associated cost and efficiency.

Prevalence and outcome of portal thrombosis in a cohort of cirrhotic patients undergoing liver transplantation.

Introduction: The prevalence of portal vein thrombosis (PVT) in patients that have undergone liver transplantation (LT) is 9.7% (SD 4.5).

Idiopathic portal hypertension regarding thiopurine treatment in patients with inflammatory bowel disease.

Introduction: The possibility of developing idiopathic portal hypertension has been described with thiopurine treatment despite compromises the prognosis of these patients, the fact its true prevalence is unknown.

Material And Methods: A cross-sectional study was conducted in a cohort of inflammatory bowel disease (IBD) patients followed at our unit, to determine the prevalence of diagnosis of idiopathic portal hypertension (IPH) and its relationship with thiopurine treatment.

Results: At the time of the analysis, 927/1,419 patients were under treatment with thiopurine drugs (65%).

Prevalence of viral hepatitis (B and C) serological markers in healthy working population.

Introduction And Objectives: prevalence of viral hepatitis (B and C) changes geographically. Our aim was to determinate the prevalence of hepatitis B (HBV) and hepatitis C virus (HCV) serological markers in healthy working population and to describe the epidemiological characteristics associated to its presence.

Methods: blood samples and epidemiological data of 5,017 healthy workers from Murcia and Madrid were recorded prospectively.

[Infliximab in ankylosing spondylitis associated with chronic hepatitis B infection. Role of Lamivudine therapy].

Anti-tumor necrosis factor-a (TNF) therapy has been associated with reactivation of hepatitis B virus infection. Case reports have suggested the concomitant need of lamivudine treatment in patients with HBV infection treated with antiTNFa agents. We describe a case of ankylosing spondylitis with positive HBV surface antigen (HBsAg) treated with infliximab and lamivudine.