A real-world evidence study of interhospital variability in the surgical treatment of patients with benign prostatic hyperplasia: the REVALURO study.

Purpose: Lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) is a growing condition in males associated with a high clinical, economic and humanistic burden. Several surgical techniques are available for the treatment of LUTS/BPH; thus, the aim of this study was to describe and explore the variability in the use of surgical procedures among Spanish hospitals.

Methods: The REVALURO was a retrospective, observational study conducted by collecting data from the clinical records of patients with LUTS/BPH aged ≥ 35 years, from 5 national reference hospitals, who were surgically treated between 2018 and 2022.

Effect of Bee Venom on Glioblastoma Cancer: In Vitro and In Vivo Studies.

Glioblastoma multiforme (GBM) is a highly aggressive and fatal primary brain tumor. The resistance of GBM to conventional treatments is attributed to factors such as the blood-brain barrier, tumor heterogeneity, and treatment-resistant stem cells. Current therapeutic efforts show limited survival benefits, emphasizing the urgent need for novel treatments.

Seed shape and size of , differences between sexes, and influence of the parental genome in hybrids with .

Introduction: Plants undergo various natural changes that dramatically modify their genomes. One is polyploidization and the second is hybridization. Both are regarded as key factors in plant evolution and result in phenotypic differences in different plant organs.

Myotoxin-3 from the Pacific Rattlesnake Venom Is a New Microtubule-Targeting Agent.

Microtubule targeting agents (MTA) are anti-cancer molecules that bind tubulin and interfere with the microtubule functions, eventually leading to cell death. In the present study, we used an in vitro microtubule polymerization assay to screen several venom families for the presence of anti-microtubule activity. We isolated myotoxin-3, a peptide of the crotamine family, and three isoforms from the venom of the Northern Pacific rattlesnake , which was able to increase tubulin polymerization.

Inhibitory effect of phenolic extract from squirting cucumber ( (L.) A. Rich) seed oil on integrin-mediated cell adhesion, migration and angiogenesis.

Integrin targeted therapies by natural bioactive compounds have attracted attention in the field of oncology and cancer treatment. This study evaluates the potential of phenolic extract from the medicinal herb L. seed oil (PEO) to inhibit the adhesion and migration of the highly invasive human fibrosarcoma cell line HT1080.

SNP markers identification by genome wide association study for chemical quality traits of coffee (Coffea spp.) Germplasm.

Background: Coffee quality is an important selection criterion for coffee breeding. Metabolite profiling and Genome-Wide Association Studies (GWAS) effectively dissect the genetic background of complex traits such as metabolites content (caffeine, trigonelline, and 5-caffeoylquinic acid (5-CQA)) in coffee that affect quality. Therefore, it is important to determine the metabolic profiles of Coffea spp.

Formalization of a new stock trend prediction methodology based on the sector price book value for the Colombian market.

As a financial indicator, Tobin's Q is related to making investment decisions based on the organization's market value related to the organization's replacement costs. The purpose of this study is to develop a methodology for predicting the trend of stock value based on the relationship between the fluctuation of Tobin's Q by sector as a trend index and the stock price variation of the Columbia stock market. To this end, a quantitative quasi-experimental survey will be conducted on shares traded by December 30, 2019.

Expression of the First Recombinant Anti-Tumoral Snake Venom Kunitz-Type Serine Protease Inhibitor.

PIVL is a Kunitz-type serine protease inhibitor that was previously characterized from Tunisian snake venom, . It reduced glioblastoma cells' development and significantly blocked angiogenesis in in-vitro and ex-vivo models. PIVL exerted these effects by interfering with αvβ3 integrin.

Strengthening Anti-Glioblastoma Effect by Multi-Branched Dendrimers Design of a Scorpion Venom Tetrapeptide.

Glioblastoma is the most aggressive and invasive form of central nervous system tumors due to the complexity of the intracellular mechanisms and molecular alterations involved in its progression. Unfortunately, current therapies are unable to stop its neoplastic development. In this context, we previously identified and characterized AaTs-1, a tetrapeptide (IWKS) from scorpion venom, which displayed an anti-proliferative effect against U87 cells with an IC value of 0.

Source of detritus and toxic elements of seabed sediments from Acapulco Bay (southern Mexico) and their ecological risk.

Total concentrations of Ba, Cd, Co, Cr, Cu, Mn, Ni, Pb, V, Zn, and As together with Sr and Pb isotopic compositions of seabed sediments from the worldwide famous tourist destination of Acapulco Bay, Guerrero (southern Mexico) were determined to reveal the origin of detritus and toxic elements (TEs), their potential natural and anthropogenic sources, elemental distribution and their ecological risk. Sediments derive entirely from the nearby Acapulco Granite and their concentrations of TEs are variable and rather low, although, several are above the Local Geochemical Baseline in some sites of the bay. The enrichment factor (EF) and Pb isotopes indicate that TEs derive from the Acapulco Granite with contributions of an anthropogenic source represented, very likely, by ship-bottom paints.

The breadth of the Mexican Transition Zone as defined by its flowering plant generic flora.

Biogeographic regions are defined by taxa with similar distribution patterns. Flowering plants have been widely used to propose biogeographic regionalization schemes because of shared historical or ecological factors that determine their distribution. The Mexican Transition Zone represents the boundary between the Nearctic and Neotropical kingdoms; however, there is no general agreement about the limits and extent of this region.

Effect of Terpenoids and Flavonoids Isolated from Kunth on TPA-Induced Ear Edema in Mice.

In this study, we isolated from the aerial parts of Kunth (i) a new neoclerodane, denominated "bacchofertone"; (ii) four known terpenes: schensianol A, bacchofertin, kingidiol and oleanolic acid; and (iii) two flavonoids: cirsimaritin and hispidulin. All structures were identified by an exhaustive analysis of nuclear magnetic resonance (NMR) and mass spectroscopy (MS). Extracts from aerial parts were screened for anti-inflammatory activity in the mice ear edema model of 12--tetradecanoylforbol-13-acetate mice.

Isolation of an Anti-Tumour Disintegrin: Dabmaurin-1, a Peptide Lebein-1-Like, from Venom.

In the soft treatment of cancer tumours, consequent downregulation of the malignant tissue angiogenesis constitutes an efficient way to stifle tumour development and metastasis spreading. As angiogenesis requires integrin-promoting endothelial cell adhesion, migration, and vessel tube formation, integrins represent potential targets of new therapeutic anti-angiogenic agents. Our work is a contribution to the research of such therapeutic disintegrins in animal venoms.

AaHIV a sodium channel scorpion toxin inhibits the proliferation of DU145 prostate cancer cells.

Prostate cancer is the most highly diagnosed cancer in men worldwide. It is characterized by high proliferation, great invasion and metastatic potential. Sodium channel subtypes have been identified as highly expressed in different prostate cancer cell lines.

Evaluation of contaminants in agricultural soils in an Irrigation District in Colombia.

This study evaluated the concentration and distribution of heavy metals (HM) (Cr, Ni, Pb, Cd, Hg, and Zn) and pesticides (organochlorine and organophosphorus) and the relationship of these pollutants with the physicochemical properties of agricultural soils in an Irrigation District (ID) in Colombia. Soils samples were analyzed for pH, humidity, organic matter, P total, N total, electric conductivity (EC), cation exchange capacity, and texture (% sand, clay and silt). Canonical correlation was used to determined relationship between soil properties and HM.

Heat processing effect of luteolin on anti-metastasis activity of human glioblastoma cells U87.

Among the flavonoïds, luteolin is a flavone that has been identified in many plants. It is known for its apoptotic potential with damage to DNA and cell cycle blockage. Many studies have shown that luteolin has anti-oxidant, anti-inflammatory, and anti-cancer activities.

RND1 regulates migration of human glioblastoma stem-like cells according to their anatomical localization and defines a prognostic signature in glioblastoma.

Despite post-operative radio-chemotherapy, glioblastoma systematically locally recurs. Tumors contacting the periventricular zone (PVZ) show earlier and more distant relapses than tumors not contacting the PVZ. Since glioblastoma stem-like cells (GSCs) have been proposed to play a major role in glioblastoma recurrence, we decided to test whether GSC migration properties could be different according to their anatomical location (PVZ+/PVZ-).

Targeting α1 inserted domain (I) of α1β1 integrin by Lebetin 2 from M. lebetina transmediterranea venom decreased tumorigenesis and angiogenesis.

Through the recent development of knowledge in biotechnology and bioinformatics, snake venoms are widely used to develop new drugs to treat diseases such as hypertension and cancer. We have previously reported that Lebetin 2 isolated from Macrovipera lebetina transmediterranea venom displays a potent anti-platelet activity and exerts a cardioprotective effect in ischemia-reperfusion (IR) injury model. Here, we report that Lebetin 2 possess an anti-tumor effect by targeting the integrin receptor function.

Native and recombinant phospholipases A of Scorpio maurus venom glands impair angiogenesis by targeting integrins α5β1 and αvβ3.

We recently purified an heterodimeric phospholipase A named Sm-PLGV from the venom glands of scorpion Scorpio maurus containing a Long chain, a penta-peptide insertion, which is cut out during the maturation, followed by a short chain. Three recombinant forms of Sm-PLGV were produced in Escherichia coli: rPLA(+5) containing the full-length sequence including the penta-peptide insert, rPLA(-5) a fused continuous chain of the Long and the short chains without the penta-peptide and the Long chain alone without the short one. In this study, we showed that Sm-PLGV, rPLA(+5) and rPLA(-5) displayed more potent anti-angiogenic properties than the recombinant Long chain and the short chain obtained by chemical synthesis.

A Low Molecular Weight Protein from the Sea Anemone with an Anti-Angiogenic Activity.

Sea anemones are a remarkable source of active principles due to a decentralized venom system. New blood vessel growth or angiogenesis is a very promising target against cancer, but the few available antiangiogenic compounds have limited efficacy. In this study, a protein fraction, purified from tentacles of , was able to limit endothelial cells proliferation and angiogenesis at low concentration (14 nM).

Helix aspersa maxima mucus exhibits antimelanogenic and antitumoral effects against melanoma cells.

Snail secretion is currently revolutionizing the world of cosmetics and human skin care. The efficacy of snail secretion in wounds healing has been proven both in vitro and by clinical studies. However, the potential anti-tumor effect of snail secretion was poorly investigated.