Publications by authors named "Jose Lourenco Reis"
Endometriosis, a debilitating condition, affects one in ten women of reproductive age. Its pathophysiology remains unclear, though deficiencies in immune surveillance are thought to create an environment conducive to the evasion of ectopic endometrial cells from the immune system. Our research explores the immunological impact of endometriosis both locally and systemically, emphasizing natural killer (NK) and T cell subpopulations.
View Article and Find Full Text PDFProblem: Endometriosis is a prevalent chronic gynecological disease linked to immune dysfunction. The protein T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) plays a crucial role in immune system balance. Malfunction of TIM-3 may result in excessive immune activation and inflammatory tissue damage.
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- Endometriosis is a chronic inflammatory condition where endometrial cells grow outside the uterus, with increasing evidence linking it to immune system dysfunction, especially involving natural killer (NK) receptors.
- A systematic review analyzed 18 studies to investigate how NK receptors, particularly inhibitory ones, are overexpressed in endometriosis, while activating receptors are decreased, suggesting a shift towards immune suppression.
- The findings propose that NK receptor activity significantly impacts the body's ability to eliminate endometriotic cells, highlighting the potential for targeting NK receptors in future therapies, similar to strategies used in cancer treatment.
HPV infection affects about 50% of sexually active individuals at least once in a lifetime. Diagnosis is made on careful inspection of the genital area and can be divided into benign lesions (genital warts or condyloma acuminatum) and pre-malignant lesions (intraepithelial neoplasia) that can lead to cancer (invasive neoplasia). Diagnostic recommendations are reviewed in Male, Female, Couple and in the immunocompromised host.
View Article and Find Full Text PDFThe authors describe the case of a forty-two-year-old patient with acute myocardial infarction (MI) on the third day of puerperium, who underwent direct angioplasty. The authors review the main physiological cardiovascular and hemostatic changes in pregnancy, which are usually well tolerated but which increase the probability of cardiovascular events when risk factors or previous cardiac disease are associated. Blood volume and cardiac output increase by around 50% during pregnancy, hemoglobin concentration falls, and reduced peripheral vascular resistance leads to a fall in arterial blood pressure during the first half of pregnancy.
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