A novel oral controlled delivery system for propranolol hydrochloride (PPL) was developed and optimized using wet granulation process. We are studying the ability of subcoating with Kollidon VA 64 as a barrier to water penetration in matrix cores combined hydrophilic (native dextran-HPMC)/hydrophobic (cetyl alcohol) prior to film coating with Opradry II-YS-30-18056. The copovidone (i.
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