Publications by authors named "Jose Le Noach"
Pulmonary nodulosis and aseptic granulomatous lung disease occurring in patients with rheumatoid arthritis receiving tumor necrosis factor-alpha-blocking agent: a case series.
J Rheumatol
November 2009
Objective: To describe cases of development of pulmonary nodulosis or aseptic granulomatous lung disease in patients with rheumatoid arthritis (RA) receiving anti-tumor necrosis factor-alpha (TNF-alpha) therapy.
Methods: A call for observation of such cases was sent to members of the French "Club Rhumatismes et Inflammation." The cases had to occur after introduction of TNF-alpha-blocking therapy.
Background: Current standard therapy for Wegener's granulomatosis and microscopic polyangiitis combines corticosteroids and cyclophosphamide to induce remission, followed by a less toxic immunosuppressant such as azathioprine or methotrexate for maintenance therapy. However, azathioprine and methotrexate have not been compared with regard to safety and efficacy.
Methods: In this prospective, open-label, multicenter trial, we randomly assigned patients with Wegener's granulomatosis or microscopic polyangiitis who entered remission with intravenous cyclophosphamide and corticosteroids to receive oral azathioprine (at a dose of 2.
Article Synopsis
- Synovial metastases are uncommon, with only 37 reported cases involving synovial fluid examination or biopsy.
- The text details a new case of chronic shoulder arthritis caused by a recurrence of rectal adenocarcinoma.
- Overall, this condition has a poor prognosis, with average survival for affected patients being less than 5 months, especially in elderly patients or those with a history of cancer.