Publications by authors named "Jose Labrador Pino"
A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut‑supporting/immune enhancing molecules.
Vijaya Iragavarapu-Charyulu Rojesh Shakya Philip Robinson Esther Guzmán Anastasia Tyulmenkova Jose Labrador Pino
Oncol Rep
February 2024
Article Synopsis
- - Patients with triple negative breast cancer (TNBC), known for poor outcomes, were studied using a mouse model (4T1Br4) to explore new treatment approaches after metastasis had occurred.
- - The combination of two anti-parasitic benzimidazoles (oxfendazole and parbendazole) was tested alongside chitin microparticles to enhance anti-cancer effects by disrupting tumor cell growth and reducing metastasis.
- - Results showed that this combined treatment significantly improved survival rates, reduced tumor and lung/brain metastasis, increased certain beneficial gut metabolites, and suggested a less aggressive cancer phenotype through increased expression of specific receptors.