Encorafenib and binimetinib followed by radiotherapy for patients with BRAFV600-mutant melanoma and brain metastases (E-BRAIN/GEM1802 phase II study).

Background: Encorafenib plus binimetinib (EB) is a standard-of-care treatment for advanced BRAFV600-mutant melanoma. We assessed the efficacy and safety of encorafenib plus binimetinib in patients with BRAFV600-mutant melanoma and brain metastasis (BM) and explored if radiotherapy improves the duration of response.

Methods: E-BRAIN/GEM1802 was a prospective, multicenter, single-arm, phase II trial that enrolled patients with melanoma BRAFV600-mutant and BM.

Eigenvalue estimates for Fourier concentration operators on two domains.

We study concentration operators associated with either the discrete or the continuous Fourier transform, that is, operators that incorporate a spatial cut-off and a subsequent frequency cut-off to the Fourier inversion formula. The spectral profiles of these operators describe the number of prominent degrees of freedom in problems where functions are assumed to be supported on a certain domain and their Fourier transforms are known or measured on a second domain. We derive eigenvalue estimates that quantify the extent to which Fourier concentration operators deviate from orthogonal projectors, by bounding the number of eigenvalues that are away from 0 and 1 in terms of the geometry of the spatial and frequency domains, and a factor that grows at most poly-logarithmically on the inverse of the spectral margin.

Efficient Computation of the Zeros of the Bargmann Transform Under Additive White Noise.

We study the computation of the zero set of the Bargmann transform of a signal contaminated with complex white noise, or, equivalently, the computation of the zeros of its short-time Fourier transform with Gaussian window. We introduce the algorithm (AMN), a variant of a method that has recently appeared in the signal processing literature, and prove that with high probability it computes the desired zero set. More precisely, given samples of the Bargmann transform of a signal on a finite grid with spacing , AMN is shown to compute the desired zero set up to a factor of in the Wasserstein error metric, with failure probability .

Zeros of Gaussian Weyl-Heisenberg Functions and Hyperuniformity of Charge.

We study Gaussian random functions on the complex plane whose stochastics are invariant under the Weyl-Heisenberg group (twisted stationarity). The theory is modeled on translation invariant Gaussian entire functions, but allows for non-analytic examples, in which case winding numbers can be either positive or negative. We calculate the first intensity of zero sets of such functions, both when considered as points on the plane, or as charges according to their phase winding.

Semi-Classical Discretization and Long-Time Evolution of Variable Spin Systems.

We apply the semi-classical limit of the generalized SO(3) map for representation of variable-spin systems in a four-dimensional symplectic manifold and approximate their evolution terms of effective classical dynamics on T*S2. Using the asymptotic form of the star-product, we manage to "quantize" one of the classical dynamic variables and introduce a discretized version of the Truncated Wigner Approximation (TWA). Two emblematic examples of quantum dynamics (rotor in an external field and two coupled spins) are analyzed, and the results of exact, continuous, and discretized versions of TWA are compared.

Multiple Sampling and Interpolation in Weighted Fock Spaces of Entire Functions.

We characterize sampling and interpolating sets with derivatives in weighted Fock spaces on the complex plane in terms of their weighted Beurling densities.

Harmonic Analysis in Phase Space and Finite Weyl-Heisenberg Ensembles.

Weyl-Heisenberg ensembles are translation-invariant determinantal point processes on associated with the Schrödinger representation of the Heisenberg group, and include as examples the Ginibre ensemble and the polyanalytic ensembles, which model the higher Landau levels in physics. We introduce finite versions of the Weyl-Heisenberg ensembles and show that they behave analogously to the finite Ginibre ensembles. More specifically, guided by the observation that the Ginibre ensemble with points is asymptotically close to the restriction of the infinite Ginibre ensemble to the disk of area , we define finite WH ensembles as adequate finite approximations of the restriction of infinite WH ensembles to a given domain .

Analysis of potential risks from the bacterial communities associated with air-contact surfaces from tilapia (Oreochromis niloticus) fish farming.

Tilapia farming is a promising growing sector in aquaculture. Yet, there are limited studies on microbiological risks associated to tilapia farms. The aim of the present study was to analyse the bacterial communities from solid surfaces in contact with air in a tilapia farm in order to evaluate the presence of bacteria potentially toxinogenic or pathogenic to humans or animals.

Resistance to Antibiotics, Biocides, Preservatives and Metals in Bacteria Isolated from Seafoods: Co-Selection of Strains Resistant or Tolerant to Different Classes of Compounds.

Multi-drug resistant bacteria (particularly those producing extended-spectrum β-lactamases) have become a major health concern. The continued exposure to antibiotics, biocides, chemical preservatives, and metals in different settings such as the food chain or in the environment may result in development of multiple resistance or co-resistance. The aim of the present study was to determine multiple resistances (biocides, antibiotics, chemical preservatives, phenolic compounds, and metals) in bacterial isolates from seafoods.

Factors influencing acceptance of disability in individuals with spinal cord injury in Neiva, Colombia, South America.

Purpose: The aim of the present study was to determine the level of acceptance of disability as measured by the Acceptance of Disability Scale (ADS) within a sample of individuals with spinal cord injury (SCI) from Neiva, Colombia and to examine the influence of sociodemographic variables, injury characteristics, and level of depression on ADS score.

Methods: The ADS was administered to 40 adults with SCI from Nieva, Colombia who were recruited from an organization that connects individuals with disabilities to resources. Most (92.

Family needs and psychosocial functioning of caregivers of individuals with spinal cord injury from Colombia, South America.

Objective: 1) To determine the most frequent needs in a group of family caregivers of individuals with spinal cord injury in Neiva Colombia; 2) to describe caregivers' psychosocial functioning; and 3) to examine the relationship between caregiver needs and caregiver psychosocial functioning.

Design: Cross-sectional.

Participants/methods: 37 caregivers completed a caregiver needs questionnaire composed of 27 questions (1-5 scale) and 9 sub-scales (emotional, information, economic, community, and household support, respite, physical health, sleep, and psychological health).

[Experience with the use of positron emission tomography (PET) in Mexico].

Background: Positron Emission Tomography (PET) is a non-invasive imaging diagnostic tool that allows the study of specific biochemical processes using labeled molecules that closely mimic endogenous molecules. The two radiopharmaceuticals used in our facility are 13N-Ammonia and 18F-2-deoxy-2 fluor D-glucose (18F-FDG). 18F-FDG is the most common radiopharmaceutical used both at our Unit as well as worldwide, as it allows the study of tumor activity, the heart's metabolic activity, distinguish viable from non-viable myocardium and assess cerebral metabolism, among others.

[Identification of acute myocardial infarction with PET and CT multislice].

Today non invasive cardiovascular imaging techniques exist, such as positron emission tomography (PET) and 16 multislice computed tomography (16-MSCT). With these studies, it is possible to evaluate the function and anatomy of the heart respectively. There is not enough information in the literature about the usefulness for 16-MSCT in the evaluation of infarcts.