Publications by authors named "Jose L Dobato"
Background And Purpose: The aim was to systematically review the effectiveness and safety of telemedicine combined with usual care (in-person visits) compared to usual care for the therapeutic management and follow-up assessment of neurological diseases.
Methods: The electronic databases MEDLINE, Embase, Web of Science and Cochrane Central Register of Controlled Trials were searched (June 2021). Randomized controlled trials (RCTs) on patients of any age with neurological diseases were considered.
Introduction: Alzheimer's disease (AD) is a major threat for the well-being of an increasingly aged world population. The physiopathological mechanisms of late-onset AD are multiple, possibly heterogeneous, and not well understood. Different combinations of variables from several domains (i.
View Article and Find Full Text PDFThe purpose of this study was to describe and compare QoL and its determinants in two groups of patients with AD that differed in place of residence: community or nursing home. This study covered 200 patients with AD (mean age 79.3 ± 8.
View Article and Find Full Text PDFWe conducted a cross-sectional study to investigate the clinical and anatomical correlates of gait dysfunction in advanced Alzheimer's disease (AD). A comprehensive clinical protocol that included cognitive, functional, behavioral, and motor variables was administered to patients with probable AD (n = 100), possible AD (n = 17), and AD with cerebrovascular disease (AD + CVD) (n = 27). Gait dysfunction was evaluated with the Rating Scale for Gait Evaluation in Cognitive Deterioration and magnetic resonance imaging was analyzed in 94 patients (volumetry study) and 78 patients (diffusion tensor imaging study).
View Article and Find Full Text PDFThe Alzheimer Center Reina Sofía Foundation (ACRSF) was envisaged to address the complex and multi-disciplinary research and care needs posed by Alzheimer's disease (AD) and other neurodegenerative dementias. Patients may be admitted at ACRSF either as inpatients (i.e.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates whether genetic variations in the tau protein phosphatase-2A (PP2A) pathway are linked to Alzheimer's disease (AD) risk by comparing late-onset AD patients with healthy controls.
- - A total of 729 AD patients and 670 healthy individuals were analyzed for specific candidate genes related to tau protein regulation, but no significant differences were found.
- - The results suggest that variations in the PP2A pathway do not have a causal relationship with the risk of developing Alzheimer's disease in the Spanish population studied.
Article Synopsis
- Tau hyperphosphorylation and neurofibrillary tangles in Alzheimer's disease are linked to the increased activity of tau kinases, which influence AD pathology.
- In a study of 729 late-onset AD patients and 670 healthy controls, a specific genetic variation in the RPS6KB2 gene was found to be more common in patients and associated with a later age of onset for AD.
- Additionally, certain genetic risk alleles from various tau kinases were linked to a later onset of AD in individuals without the APOE ε4 allele, while a specific CDC2 haplotype provided a protective effect against AD.
Background: The clinical features of cluster headache (CH) disclose some vascular changes in the symptomatic region, but few instrumental studies have assessed orbital hemodynamics in patients with this disorder.
Methods: Orbital blood flow reactivity elicited by Valsalva maneuver (VM) was studied with ophthalmic artery eco-Doppler in 16 patients (14 men and 2 women; mean age: 41.2) suffering from episodic CH and in 18 healthy controls.
Objective: To study the clinical features of nummular headache (NH) and get an approach to its epidemiology.
Background: NH has been recently described as a primary disorder characterized by head pain exclusively felt in a small rounded area typically 2-6 cm in diameter.
Methods: Through a 1-year period we have studied all patients referred to our neurologic clinic because of head pain exclusively felt in a small-circumscribed area, and not attributed to another disorder.