Publications by authors named "Jose Jg Marin"
Article Synopsis
- Cholangiocarcinoma (CCA) is a rare type of biliary cancer that has increasing incidence and mortality, varying by subtype: intrahepatic (iCCA), perihilar (pCCA), and distal (dCCA), with different risk factors and clinical courses.
- In a study with 2,234 patients from the ENSCCA Registry, results showed that iCCA is often linked to obesity and chronic liver issues, while pCCA involves primary sclerosing cholangitis, and dCCA relates to choledocholithiasis; most patients are diagnosed with advanced disease, complicating treatment outcomes.
- Surgical resection provided the best survival rates, especially with clear margins, while patients with
Until recently, cholangiocarcinoma (CCA) was a largely overlooked disease, and among CCAs, extrahepatic CCA (eCCA) was even more neglected. Despite the growing impact of molecularly targeted therapies and immunotherapy, prognosis of eCCA is dismal. Therefore, unraveling the complex molecular landscape of eCCA has become an urgent need.
View Article and Find Full Text PDFAn important factor determining the pharmacological response to antitumor drugs is their concentrations in cancer cells, which accounts for the net interaction with their intracellular molecular targets. Accordingly, mechanisms leading to reduced intracellular levels of active agents play a crucial role in cancer chemoresistance. These include impaired drug uptake through solute carrier (SLC) proteins and efficient drug export by ATP-dependent pumps belonging to the ATP-binding cassette (ABC) superfamily of proteins.
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