Antinociceptive Synergy Between Metamizole and Hesperidin in a Model of Visceral Pain in Mice.

Background: Metamizole is used to relieve the visceral pain but its adverse effects limit its use. An alternative to improve its efficacy with lower doses is to combine it with a natural product as hesperidin.

Aim Of The Study: The aim of this study was to evaluate the antinociceptive interaction between metamizole and hesperidin in a visceral pain model using an isobolographic analysis.