Publications by authors named "Jose Ignacio Elizalde"
Article Synopsis
- Gastric cancer (GC) is a common and deadly cancer, with bone metastasis (BM) occurring in 1-20% of cases, leading to a prognosis that is significantly worsened for patients.
- A study of 118 GC patients revealed that 8 (6.8%) developed BM, predominantly in advanced stages, with symptoms often being non-specific and requiring imaging for detection.
- The research highlights the increased awareness of osteoblastic BM in GC, emphasizes the need for regular monitoring, and calls for better integration between oncology and palliative care to enhance patient well-being and suggests further study on effective management approaches.
To adopt prevention strategies in gastric cancer, it is imperative to develop robust biomarkers with acceptable costs and feasibility in clinical practice to stratified populations according to risk scores. With this aim, we applied an unbiased genome-wide CpG methylation approach to a discovery cohort composed of gastric cancer ( = 24), and non-malignant precursor lesions ( = 64). Then, candidate-methylation approaches were performed in a validation cohort of precursor lesions obtained from an observational longitudinal study ( = 264), with a 12-year follow-up to identify repression or progression cases.
View Article and Find Full Text PDFBackground: Digestive damage due to Chagas disease (CD) occurs in 15-20% of patients diagnosed as a result of peristaltic dysfunction in some endemic areas. The symptoms of chronic digestive CD are non-specific, and there are numerous confounders. Diagnosis of CD may easily be missed if symptoms are not evaluated by a well trained physician.
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