Publications by authors named "Jose I Vela-Segarra"
Article Synopsis
- Purpose of the Study
- : The research aimed to investigate the changes in retinal microvasculature and sensitivity in patients with type 1 diabetes (T1D) before the onset of diabetic retinopathy (DR).
- Methods and Findings
- : In total, 62 eyes from 31 T1D patients (without DR and with mild DR) and 40 eyes from 20 healthy controls were examined using OCTA for vascular parameters and microperimetry for retinal sensitivity. No significant differences in retinal measurements were found between the T1D groups but notable differences were observed when compared to healthy controls.
- Conclusions
- : The study concluded that patients with T1D, even without DR
Purpose: To describe a unique complication of macular hole repair surgery using a subretinal human amniotic membrane plug.
Methods: Retrospective, interventional case report.
Results: A 71-year-old man presented with a chronic full-thickness macular hole in his left eye.
Bilateral macular hole is a rare secondary effect of tamoxifen, a condition which is probably underdiagnosed. We describe the case of a 63-year-old woman who had received low-dose treatment with tamoxifen for 10 years. She presented with a best-corrected visual acuity of 20/40 in both eyes and bilateral macular hole with posterior hyaloid attachment.
View Article and Find Full Text PDFObjectives: Our aim was to determine the molecular cause of autosomal dominant familial retinal arteriolar tortuosity (FRAT) in a family with three affected subjects.
Material And Methods: Ophthalmologic evaluation included determination of best-corrected visual acuity (BCVA), slit-lamp and dilated fundus inspection, applanation tonometry, fundus photography, and fluorescein retinal angiography (FA). Molecular methods included whole exome sequencing analysis and Sanger sequencing validation of putative causal mutation in DNA from affected individuals.
Purpose: To describe the clinical and genetic characteristics of the second family with a recently described recessive syndrome characterized by posterior microphthalmos, retinitis pigmentosa, foveoschisis, and optic disk drusen.
Design: Observational case report.
Methods: Three affected subjects and one healthy sibling from a consanguineous marriage from Spain were studied.