Publications by authors named "Jose I Vargas"

Barrett's esophagus (BE) is the condition in which a metaplastic columnar mucosa predisposed to neoplasia replaces the squamous mucosa of the distal esophagus. The current guidelines recommends that diagnosis requires the finding of intestinal metaplasia (IM) with goblet cells of at least 1 cm in length. BE affects approximately 1% of the general population and up to 14% of patients with gastroesophageal reflux disease (GERD).

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Unlabelled: Latin America presents a high prevalence of Helicobacter pylori(Hp) infection. Between1996-2003, the prevalence in Santiago, Chile, was 70%; recent studies indicate a decreasein this infection. Updating the frequency of Hp is crucial due to its associated health impact.

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Background: Small bowel tumors (SBT) are infrequent and represent a small proportion of digestive neoplasms. There is scarce information about SBT in Latin America.

Aim: To describe the epidemiology, clinical characteristics, diagnostic methods, and survival of malignant SBTs.

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Apparent metabolizable energy (AME) and apparent ileal amino acid digestibility (AIAAD) of corn samples from the United States (USA), Argentina (ARG), and Brazil (BRA) fed to 432 and 324 YPM × Ross 708 male broilers from 12 to 18 d of age were evaluated using the total collection method (experiment 1) and index method (experiment 2), respectively. In experiment 1, broilers were fed either a basal diet with 30% dextrose inclusion, or a test diet obtained by the replacement of dextrose with corn from each origin. In experiment 2, broilers were fed one of three test diets in which corn from each origin was the only source of AA.

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Background: The updated Sydney system biopsy protocol (USSBP) standardizes the sampling of gastric biopsies for the detection of preneoplastic conditions (e.g., gastric intestinal metaplasia [GIM]), but the real-world diagnostic yield is not well-described.

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This experiment studied the effect of feeding corn from the United States (USA), Argentina (ARG), and Brazil (BRA) on broiler performance, processing yield, and nutrient digestibility from 1 to 35 d of age. A total of 900-day old YPM × Ross 708 male broilers were randomly sorted in 36 floor pens, each containing 25 chicks and subjected to three experimental diets, resulting in 12 replications per dietary treatment. Starter, grower, and finisher diets were formulated to be only different in corn origin.

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Nutritional additives such as propolis seek to improve intestinal health as an alternative to the global ban on in-feed antibiotics used as growth promoters (AGP). The objective of this study was to evaluate the effect of propolis supplementation in diet of broilers. Four hundred and fifty straight-run Ross 308 AP broilers were fed with a basal diet (BD) throughout the whole experimental period.

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Pancreatic cystic neoplasms (PCN) are frequently detected on abdominal images performed for non-pancreatic indications. Their prevalence in asymptomatic population ranges from 2.7 to 24.

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Article Synopsis
  • - A new standardized scoring system called the Toronto Upper Gastrointestinal Cleaning Score (TUGCS) was developed to improve the assessment of mucosal visualization during esophagogastroduodenoscopy (EGD) using a consensus methodology involving expert feedback.
  • - After three rounds of review with 14 experts, the TUGCS showed high inter-rater reliability (0.79) and strong test-retest reliability (0.83), indicating consistent results among different assessors over time.
  • - The TUGCS demonstrated strong validity, correlating positively with an independent assessment of mucosal visualization, suggesting it could be widely adopted in clinical practice for better EGD quality assessment.
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Background: Adenocarcinoma is preceded by chronic atrophic gastritis, gastric intestinal metaplasia and dysplasia. Trefoil factor 3 (TFF3) is a peptide secreted by goblet cells, which is abundantly present in intestinal metaplasia.

Aim: To evaluate the utility of serum TFF3 as a non-invasive biomarker for the diagnosis of intestinal metaplasia and gastric cancer.

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Introduction: Helicobacter pylori infection affects approximately 70% of the Chilean population. It is a public health problem whose eradication treatment is part of the explicit health guarantees in Chile.

Objectives: Characterize the most widely used H.

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HCV infection is associated with an increased incidence of cardiovascular (CV) events. Mechanisms underlying this association remain unknown. In our study, twenty HCV patients (median age 60.

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Importance: Active immunization for hepatitis B virus (HBV) infection is recommended in patients living with HIV. Limited evidence is available about the most appropriate regimen of HBV vaccination among those who have not responded to an initial schedule.

Objective: To determine the efficacy of a high-dose schedule compared with a standard dose of HBV vaccination.

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Chile has become a popular destination for migrants from South America and the Caribbean (low- and middle-income countries migration). Close to 200.000 Haitian migrants have arrived in Chile.

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Background & Aims: Steatohepatitis drives fibrogenesis in alcohol-related liver disease. Recent studies have suggested that hepatic stellate cells (HSCs) may regulate the parenchymal cell injury and inflammation that precedes liver fibrosis, although the mechanism remains incompletely defined. Neuropilin-1 (NRP-1) and synectin are membrane proteins implicated in HSC activation.

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Background And Aim: Upper GI endoscopy (UGE) is essential for the diagnosis of gastrointestinal diseases. Mucus and bubbles may decrease mucosal visibility. The use of mucolytics could improve visualization.

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Purpose Of Review: The purpose of this study is to analyze the current evidence regarding the use of statins in patients with chronic liver disease and cirrhosis.

Recent Findings: Chronic liver disease (CLD), cirrhosis, and its complications, including hepatocellular carcinoma (HCC), are significant public health problems. The use of statins in patients with CLD has been a matter of concern, and physicians are often reluctant to its prescription in these patients.

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