Publications by authors named "Jose H G Balbinotti"
Article Synopsis
- Environmental pollution and the presence of the TP53 p.R337H variant are key factors in cancer risk in Paraná, Brazil.
- A study assessed breast cancer risk in rural and industrialized areas, finding that C2 had lower organochloride levels and cancer risks compared to C1 and C3.
- Among women over 30, TP53 p.R337H carriers had 4.58 times higher breast cancer risk, with lower prevalence and mortality rates observed in C2 than in the other subregions.
Penetrance of the R337H Mutation and Pediatric Adrenocortical Carcinoma Incidence Associated with Environmental Influences in a 12-Year Observational Cohort in Southern Brazil.
Tatiana E J Costa Viviane K Q Gerber Humberto C Ibañez Viviane S Melanda Ivy Z S Parise José H G Balbinotti
Cancers (Basel)
November 2019
The R337H mutation is associated with increased incidence of pediatric adrenocortical tumor (ACT). The different environmental conditions where R337H carriers live have not been systematically analyzed. Here, the R337H frequencies, ACT incidences, and R337H penetrance for ACT were calculated using the 2006 cohort with 4165 R337H carriers living in Paraná state (PR) subregions.
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