Publications by authors named "Jose Gonzalez Chavez"

Background: Bile atresia is children's leading cause of cirrhosis. Its high morbidity and mortality are explained by its complications, including gastrointestinal bleeding and portal hypertension. Umbilical hernia has been embryologically and clinically associated with portal hypertension and cirrhosis; however, the clinical evolution of patients with bile atresia and umbilical hernia is unknown, so the aim of the study is to describe this link.

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  • - Hailey-Hailey disease is an autosomal dominant condition caused by a mutation in the ATP2C1 gene, leading to painful skin blisters and erosions, particularly in folds of the skin.
  • - There is currently no cure for the disease, and treatments mainly focus on managing infections and inflammation, with a recent emphasis on targeting the disease's biochemical pathways.
  • - In a case series involving three patients with severe Hailey-Hailey disease, the use of the biologic drug adalimumab successfully controlled their symptoms and maintained remission.
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  • Mevalonate kinase deficiency is a rare genetic disorder caused by mutations in the MVK gene, leading to various autoinflammatory diseases, including hyper-IgD syndrome and mevalonic aciduria.
  • Approximately 300 cases have been documented globally, showcasing its rarity.
  • A 3-year-old girl from Puerto Rico was diagnosed with hyper-IgD syndrome after experiencing fever, joint pain, and skin lesions from an early age; she will be treated with canakinumab following routine vaccinations.
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Background: Testicular infiltration is infrequent in pediatric patients with leukemia and can be confused with other testicular conditions.

Objective: To analyze the presence of clinical and radiological features suggestive of testicular disease and its histological association with leukemia infiltration.

Method: Retrospective and analytical observational study that included patients with diagnosis of leukemia who underwent biopsy for suspected testicular infiltration.

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Acid mine drainage (AMD) causes major environmental problems and consequently, several treatments are proposed, favoring the passive systems because of their many advantages. The main goal of these procedures is the neutralization and removal of potentially toxic elements (PTE), yet little is known about the changes in the microbial assemblages in response to the hydrochemical variations during the treatments. Therefore, the main objective of this research was to determine the changes in the diversity and structure of the prokaryotic assemblages in a hybrid abiotic and biological (wetland) passive treatment system.

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Background: The aim of this study was to assess the frequency of allopathic and complementary medicine use for preventing the infection with SARS-CoV-2 in Mexico. A descriptive and cross-sectional study was conducted using an online questionnaire among general adult population (n = 16,724) of the 32 Mexican states from March to November 2020.

Methods: The factors associated with the use, self-medication practice, and adverse reactions due the consumption of allopathic and complementary medicine to prevent infection with SARS-CoV-2 virus were assessed using a structured questionnaire.

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Nitrates and perchlorates are present both on Earth and Mars. In the Martian environment perchlorates dominate over nitrates whereas on Earth is contrariwise. This implies that the mechanisms responsible for their formation are different for both planets.

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Extracorporeal photopheresis (ECP) was hailed as a new therapeutic concept for the treatment of diseases caused by aberrant T lymphocytes since it was first described more than twenty years ago. Advances in molecular biology and immunology have allowed a greater understanding of the mechanisms involved in ECP. As a result, ECP is being increasingly considered as a safe and promising immunomodulatory therapy with diverse clinical applications.

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Lupus erythematosus has a wide spectrum of cutaneous manifestations, including periorbital mucinosis. We report 3 cases of periorbital mucinosis occurring in association with other cutaneous signs of lupus erythematosus. Based on a review of the literature, periorbital mucinosis is a rare and not widely recognized clinical manifestation of the disease.

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Background: Although major advances in the understanding of its pathogenesis have been achieved, psoriasis remains an incurable disease. In April 2004, etanercept, an antagonist of TNF-alpha, was approved by the Food and Drug Administration for the treatment of chronic, moderate to severe plaque psoriasis in adults. In this study we intend to document the efficacy and further establish the safety profile of etanercept for the treatment of moderate to severe psoriasis in our population and compare our data to the Leonardi et al study published in 2003.

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