Publications by authors named "Jose Gaston Guillem"
Background & Aims: The intestinal barrier comprises a monolayer of specialized intestinal epithelial cells (IECs) that are critical in maintaining mucosal homeostasis. Dysfunction within various IEC fractions can alter intestinal permeability in a genetically susceptible host, resulting in a chronic and debilitating condition known as Crohn's disease (CD). Defining the molecular changes in each IEC type in CD will contribute to an improved understanding of the pathogenic processes and the identification of cell type-specific therapeutic targets.
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- The study investigates the expression of ACE2 in colonic tissues of Crohn's disease (CD) patients compared to non-inflammatory bowel disease (non-IBD) controls.
- ACE2 was found to be significantly higher in a subset of CD patients, termed ACE2-high CD patients, who are at greater risk of needing surgery within five years of diagnosis.
- This research suggests that increased ACE2 expression is linked to worse clinical outcomes in CD and highlights the potential for tailored treatment strategies based on ACE2 levels.
Background And Aims: The host receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small intestine. Our aim was to study colonic ACE2 expression in Crohn's disease (CD) and non-inflammatory bowel disease (non-IBD) controls. We hypothesized that the colonic expression levels of ACE2 impacts CD course.
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