Publications by authors named "Jose G Macias-Barragan"
Article Synopsis
- The G Protein-Coupled Estrogen Receptor (GPER) has been found to play a significant role in cervical cancer, showing its potential as a target for treatment despite limited research on its effects.
- GPER was notably expressed in cervical cancer tissues, with its stimulation by an agonist (G-1) leading to decreased cell proliferation and increased apoptosis in various cervical cancer cell lines.
- The findings indicate that GPER may serve as a promising pharmacological target for preventing cervical cancer progression by inducing cell death mechanisms.
Effects of 60 kDa prolactin and estradiol on metabolism and cell survival in cervical cancer: Co‑expression of their hormonal receptors during cancer progression.
Annie Riera-Leal Adrián Ramírez De Arellano Inocencia Guadalupe Ramírez-López Edgar I Lopez-Pulido Judith R Dávila Rodríguez
Oncol Rep
December 2018
Estrogens and estrogen receptors (ERs), such as ERα and ERβ, prolactin (PRL) and prolactin receptor (PRLR) have been reported to be involved in the physiopathology of uterine cervical cancer (UCC). The 60 kDa PRL is an isoform of PRL, which is produced by UCC‑derived cells. The present study aimed to evaluate the expression of hormonal receptors in different degrees of cervical lesions, and to determine whether 60 kDa PRL and 17β‑estradiol (E2) modulated cell survival and metabolism in UCC cells, and in HaCaT cells transduced with human papillomavirus (HPV) 16 and 18 E6/E7 oncogenes.
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