Cathepsin L3 From Induces NLRP3 Inflammasome Alternative Activation in Murine Dendritic Cells.

The production of IL-1-family cytokines such as IL-1β and IL-18 is finely regulated by inflammasome activation after the recognition of pathogens associated molecular pattern (PAMPs) and danger associated molecular patterns (DAMPs). However, little is known about the helminth-derived molecules capable of activating the inflammasome. In the case of the helminth trematode , the secretion of different cathepsin L cysteine peptidases (FhCL) is crucial for the parasite survival.

Fasciola hepatica mucin-encoding gene: expression, variability and its potential relevance in host-parasite relationship.

Fasciola hepatica is the causative agent of fasciolosis, a zoonosis with significant impact both in human and animal health. Understanding the basic processes of parasite biology, especially those related to interactions with its host, will contribute to control F. hepatica infections and hence liver pathology.