Publications by authors named "Jose Fabian Martinez-Herrera"

Introduction: Lung cancer continues to be the leading cause of death among cancer patients worldwide. This study aimed to estimate the clinical, economic, and social burdens of stage IV non-small cell lung cancer (NSCLC) in private and public healthcare centers in Mexico, utilizing real-world evidence.

Methods: The study population included patients >18 years of age diagnosed with stage IV NSCLC who received cancer treatment at the Centro Médico Nacional Siglo XXI (IMSS), the Centro Médico Nacional "20 de Noviembre" (ISSSTE), the Mexican Institute of Respiratory Diseases (INER), and the Medical Center ABC (American British Cowdray) from 1 January 2019 to 31 December 2020.

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  • Melanoma treatment has significantly advanced with checkpoint blockade immunotherapy (CBI), focusing on understanding immune cell interactions within tumors for better responses to therapy.
  • The study utilized advanced techniques to analyze two cohorts of melanoma patients—one without treatment and another receiving immunotherapy—highlighting the role of tissue-resident memory (TRM) CD8 T cells and dendritic cells in cancer immunity.
  • Findings revealed two distinct TRM CD8 T cell subsets (TCF1+ and TCF1-) that exhibit different protein expressions linked to melanoma protection, with their spatial distribution in tumors being crucial for understanding their impact on treatment outcomes.
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Background: Lung cancer represents a significant global health concern, often diagnosed in its advanced stages. The advent of massive DNA sequencing has revolutionized the landscape of cancer treatment by enabling the identification of target mutations and the development of tailored therapeutic approaches. Unfortunately, access to DNA sequencing technology remains limited in many developing countries.

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  • Venous thromboembolism (VTE) is a frequent issue in cancer patients, with treatments like low-molecular-weight heparins (LMWHs) and direct oral anticoagulants (DOACs) showing effectiveness and safety.
  • A systematic review included five randomized controlled trials comparing the effectiveness of apixaban and dalteparin in managing cancer-related VTE.
  • The results indicated that while apixaban had a lower risk of recurrent VTE than dalteparin, the difference wasn't statistically significant; however, apixaban did show a significant reduction in clinically relevant non-major bleeding compared to dalteparin.
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Acral melanoma (AM) is the most common melanoma in non-Caucasian populations, yet it remains largely understudied. As AM lacks the UV-radiation mutational signatures that characterize other cutaneous melanomas, it is considered devoid of immunogenicity and is rarely included in clinical trials assessing novel immunotherapeutic regimes aiming to recover the antitumor function of immune cells. We studied a Mexican cohort of melanoma patients from the Mexican Institute of Social Security (IMSS) (n = 38) and found an overrepresentation of AM (73.

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Background: An up-to-date analysis of gastric cancer mortality among Hispanic/Latino populations is required for estimating disease burden and assessing the effectiveness of clinical and preventive strategies.

Methods: We retrieved gastric cancer deaths between 1997 and 2017 (as available) from the Surveillance, Epidemiology, and End Results Program (United States Hispanics) and the World Health Organization databases (Puerto Rico, 16 Latin American and Caribbean countries). Joinpoint regression analysis was used to examine trends in age-standardized mortality rates (ASMR; per 100 000 person-years) and calculate average annual percent changes (AAPCs) by country (or territory), age group (25-49 and ≥50 years), and sex.

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  • The study analyzed prostate cancer mortality trends in Peru from 2003 to 2017 using data from the Ministry of Health.
  • A total of 38,617 prostate cancer deaths were reported, with a notable decline in mortality rates, especially in the coastal region, while the highlands and rainforest regions showed stable trends.
  • The findings highlight significant health care disparities across different geographical areas, emphasizing the need for targeted public health efforts to address the high mortality burden, particularly in rainforest provinces.
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  • Lung cancer remains the leading cause of cancer-related deaths globally, with significant mortality rates reported in Peru, although accurate data is hindered by under-reporting.
  • A study analyzing lung cancer mortality trends from 2008 to 2017 in Peru found that mortality rates were higher in males, with regional differences showing declines on the coast but increases in the highlands, especially in Apurimac.
  • The analysis highlighted higher smoking prevalence in males, especially young adults, suggesting that public health measures targeting smoking reduction are essential to lower lung cancer mortality rates in the country.*
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Background: Immunotherapy has demonstrated an improved overall survival (OS) and progression-free survival (PFS) as second-line treatment and subsequent lines compared with chemotherapy.

Materials & Methods: This was a retrospective review among eight medical centers comprising 100 patients with a confirmed diagnosis of non-small-cell lung carcinoma, in their second-line treatment or beyond with immune checkpoints inhibitors treatment. The current study aimed to analyze effectiveness of immunotherapy in second-line treatment or further in the Mexican population, using PFS rate, OS rate and the best objective response to treatment by RECIST 1.

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Background: Malignant pleural mesothelioma is an infrequent neoplasia with a poor prognosis and the majority of patients already have advanced disease at the time of presentation. Exposure to asbestos is the most important risk factor for malignant pleural mesothelioma. Mesothelioma is a neoplasia with a long preclinical stage that can span from 15 to 40 years.

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  • Breast cancer (BC) is the most common cancer among women in Latin America, with varying mortality rates; this study specifically examines BC mortality in Peru over 15 years.
  • The age-standardized mortality rate for BC in Peru was 9.97 per 100,000 women-years, with the coastal region facing the highest rates, especially in provinces like Tumbes, Callao, and Moquegua by 2017.
  • While the coastal region shows a declining mortality trend since 2005, the highlands region experienced a significant increase, highlighting the need for targeted public health strategies to address these disparities.
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  • The study examined the connection between EGFR signaling pathways in skin samples and the response of lung cancer patients to targeted therapies, specifically tyrosine kinase inhibitors.
  • It analyzed 35 skin biopsies from 31 patients with EGFR-mutated lung adenocarcinoma, using various immunohistochemical methods to assess treatment response.
  • Findings indicated that certain markers (EGFR, Ki67, STAT3) in skin samples correlated with better treatment outcomes and progression-free survival, suggesting that skin biopsies could be useful in evaluating cancer therapies.
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Patients with triple-negative breast cancer (TNBC) have a poor prognosis, partly because of the absence of targeted therapies. Recognition of the key role of immune responses against cancer has allowed the advent of immunotherapy, focused on the inhibition of negative immune checkpoints, such as CTLA-4. CTLA-4 is also expressed in some cancer cells, but its activity in tumor cells is not completely understood.

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Objective: To evaluate the mortality rates for prostate cancer according to geographical areas in Peru between 2005 and 2014.

Materials And Methods: Information was extracted from the Deceased Registry of the Peruvian Ministry of Health. We analysed age-standardised mortality rates (world population) per 100 000 men.

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Introduction: There are few studies regarding the clinical characteristics of Miller Fisher syndrome (MFS) in the Latin-American population.

Methods: A retrospective analysis was made of the clinical characteristics, neurophysiology, treatment and prognosis of MFS patients between 1995 and 2005.

Results: Nineteen MFS cases were documented, 12 of which did not receive immunosuppressive therapy.

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