Publications by authors named "Jose F Cantillo"
Article Synopsis
- Mosquito allergy manifests mainly as skin reactions during and after bites, along with other allergic responses like asthma, linked to different allergens from the mosquitoes.
- There are two primary types of mosquito allergy: cutaneous reactions triggered by salivary allergens and respiratory reactions due to somatic allergens, with cutaneous reactions being the main focus of research.
- Despite limited studies on immunotherapy for mosquito-related allergies, symptom management and preventative measures against mosquito bites remain the primary approaches in clinical practice, highlighting a need for further research in this area.
The mouse Igh locus is organized into a developmentally regulated topologically associated domain (TAD) that is divided into subTADs. Here we identify a series of distal V enhancers (Es) that collaborate to configure the locus. Es engage in a network of long-range interactions that interconnect the subTADs and the recombination center at the DJ gene cluster.
View Article and Find Full Text PDFBackground: Allergen Immunotherapy (AIT) is an effective treatment of allergic respiratory diseases induced by the inhalation of house dust mite allergens.
Objectives: To evaluate the efficacy and safety of glutaraldehyde polymerized allergen extracts using a mixture of and in mite allergic individuals residing in Colombia.
Methods: Two hundred and fifty (250) patients with allergic rhinoconjunctivitis with, or without asthma and sensitized to and were included.
Article Synopsis
- * Global warming has led to the invasion of new mosquito species in different areas, affecting the diagnosis and understanding of mosquito allergies, which can trigger conditions like asthma and rhinitis.
- * The article highlights the need for improved diagnostic methods for mosquito allergies, suggesting the use of purified recombinant allergens instead of less effective saliva-based or whole-body extracts.
Class-switch recombination (CSR) involves replacement of the Cμ constant region with another downstream C region. CSR is initiated by activation-induced cytidine deaminase (AID)-mediated DNA breaks that are targeted to transcriptionally active switch (S) regions. S region promoters (Prs) direct synapsis by associating with the Eμ and 3'Eα enhancers that jointly anchor a chromatin loop.
View Article and Find Full Text PDFChicken MBD4 Regulates Immunoglobulin Diversification by Somatic Hypermutation.
Front Immunol
November 2020
Immunoglobulin (Ig) diversification occurs via somatic hypermutation (SHM) and class switch recombination (CSR), and is initiated by activation-induced deaminase (AID), which converts cytosine to uracil. Variable (V) region genes undergo SHM to create amino acid substitutions that produce antibodies with higher affinity for antigen. The conversion of cytosine to uracil in DNA promotes mutagenesis.
View Article and Find Full Text PDFThe house dust mite (HDM) is an important risk factor for asthma and rhinitis. Allergen specific immunotherapy that is based on recombinant proteins has been proposed for the safer and more efficient treatment of allergic diseases. The aim of this study was to design and obtain a hybrid protein (DPx4) containing antigenic regions of allergens Der p 1, Der p 2, Der p 7, and Der p 10 from this mite.
View Article and Find Full Text PDFBackground: Papular urticaria (PU) is a common insect bite skin hypersensitivity in tropical countries. In order to gain insight into its causal allergens, we aimed to evaluate cellular and humoral immune responses to the recombinant salivary antigen Cte f 2 from the cat flea Ctenocephalides felis.
Method: Sixty patients with PU and 27 healthy controls were included in this study.
Background: Aedes aegypti and Dermatophagoides pteronyssinus contain important allergens including cross-reactive tropomyosins. However, the functional and clinical relevance of their cross-reactivity is still debated.
Objective: To analyse the humoral and cellular cross-reactivity of recombinant Aed a 10.
Article Synopsis
- Sensitization to house dust mite allergens is a key contributor to asthma and allergic diseases, leading researchers to develop new allergy therapies using modified recombinant allergens.
- A hybrid molecule called MAVAC-BD-2 was created, incorporating multiple allergens from two different types of house dust mites and tested for its effectiveness in reducing allergic reactions.
- The results showed that MAVAC-BD-2 has hypoallergenic properties and can stimulate the production of IgG antibodies in mice, which help to block allergic responses to common mite allergens in humans.
Objective: To provide information about the complexity of skin-derived mammalian allergen extracts and recent advances made in their characterization and production.
Data Sources: Original and review articles (involving nonfood allergy to mammals) published in indexed journals were searched in the PubMed database.
Study Selections: Studies were selected with the following criteria: novelty, species of the study, and date of publication.
Article Synopsis
- Cross-reactivity between Aedes aegypti (a mosquito species) and other allergens like mites, cockroaches, and shrimp was studied, revealing the presence of shared molecular components.
- The research analyzed serum samples from asthma and allergic rhinitis patients to measure specific IgE levels and investigate cross-reactivity using various allergenic extracts and proteins.
- Findings showed a high frequency of IgE reactivity, particularly between Aedes aegypti and mites, and identified four novel cross-reactive allergens that may affect allergic reactions in tropical environments.
Identification and Characterization of IgE-Binding Tropomyosins in Aedes aegypti.
Int Arch Allergy Immunol
February 2017
Article Synopsis
- The study focuses on the allergenic potential of the mosquito Aedes aegypti, specifically investigating its tropomyosin, a protein that may trigger allergic reactions.
- Researchers isolated and analyzed natural and recombinant variants of tropomyosin, finding that some of these variants reacted with the IgE antibodies of allergic patients and showed cross-reactivity with similar proteins from other species like house dust mites and shrimp.
- The findings indicate that tropomyosin could be a significant IgE-binding allergen from A. aegypti, with different variants having varying levels of cross-reactivity, highlighting the need for further research on their allergenic properties.
Immunological aspects of the immune response induced by mosquito allergens.
Int Arch Allergy Immunol
April 2015
Article Synopsis
- Mosquito bites can trigger local or systemic allergic reactions, and inhaling mosquito allergens may lead to asthma or allergic rhinoconjunctivitis in sensitive individuals.
- Immune responses to these allergens involve antibodies (IgE and IgG), proinflammatory cytokines, and immune cells like basophils and eosinophils, with certain mosquito species, primarily Aedes, Culex, and Anopheles, being the most common culprits.
- Advances in identifying mosquito allergens, particularly from Aedes aegypti, have led to the development of diagnosis methods and allergen-specific immunotherapy that reduces allergic symptoms and medication needs.
Article Synopsis
- * However, these natural extracts are complex and difficult to standardize, leading to increased risks such as anaphylactic shock and potential sensitization to other allergens.
- * New approaches using chemically defined and standardized antigens are being developed, including vaccines based on recombinant allergens, which show promise in improving treatment safety and effectiveness through various immune responses.