Publications by authors named "Jose Emilio Hernandez-Barcelo"
Associations between dyslipidemia and metabolic dysfunction-associated steatotic liver disease (MASLD) have been reported. Previous studies have shown that the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio may be a surrogate marker of MASLD, assessed by liver ultrasound. However, no studies have evaluated the utility of this ratio according to biopsy-proven MASLD and its stages.
View Article and Find Full Text PDFFraser syndrome or cryptophthalmos-syndactyly syndrome is a rare genetic disease, the diagnosis of which is based on a series of major and minor clinical criteria and that can be supported by genetic tests. This article presents the case of a fetal autopsy at 37 weeks of gestation with suspicion of CHAOS syndrome (congenital obstructive syndrome of the upper airways).
View Article and Find Full Text PDFArticle Synopsis
- Predictive biomarkers for trabectedin in advanced soft-tissue sarcomas (STS) remain an unmet need, with previous studies focusing on a limited number of DNA damage repair (DDR) genes.
- Through a retrospective study, a new six-gene predictive signature for trabectedin efficacy was developed by analyzing 118 DDR-related genes in 139 tumor samples, revealing significant differences in progression-free survival between high-risk and low-risk groups.
- The study identified potential new biomarkers for sensitivity (PARP3, CCNH) and resistance (DNAJB11, PARP1) to trabectedin, suggesting that targeting these genes could improve treatment outcomes.