The effect of simvastatin on the regeneration of surgical cavities in the femurs of rabbits.

Purpose: To evaluate the effect of a local application of simvastatin gel in repairing bone defects in the femurs of rabbits.

Methods: Two standard surgical cavities were created in the femoral epiphysis of 18 rabbits. In the simvastatin group (SG), the cavities were filled with a collagen sponge soaked in 0.