UPLC-HDMS to discover serum biomarkers in adults with type 1 diabetes.

Type 1 diabetes (T1D) is a complex disease with metabolic and functional changes that can alter an individual's proteome. An LC-MS/MS analytical method, in an HDMS system, was used to identify differentially expressed proteins in the high abundance protein-depleted serum of T1D patients and healthy controls. Samples were processed in Progenesis QI for Proteomics software.

New insights about the EptA protein and its correlation with the gene in polymyxin resistance in .

Nowadays, clinical and scientific interest in antibiotics, as polymyxin, has increased due to the large number of reports of multiresistant Gram-negative bacteria, as . The aim of this study was to investigate a related group of proteins for resistance to polymyxins, encoded by genome, through analysis. The mobilized colistin resistance 1 (MCR) protein from was used for comparison Similar sequences to the protein MCR in were analysed for physicochemical properties.

SARS-COV-2 infection outcomes in patients with congenital generalized lipodystrophy.

Background: A new strain of human coronavirus (HCoV) spread rapidly around the world. Diabetes and obesity are associated with a worse prognosis in these patients. Congenital Generalized Lipodystrophy (CGL) patients generally have poorly controlled diabetes and require extremely high doses of insulin.

Bioethical conflicts of gene therapy: a brief critical review.

Methods and techniques employed in gene therapy are reviewed in parallel with pertinent ethical conflicts. Clinical interventions based on gene therapy techniques preferentially use vectors for the transportation of therapeutic genes, however little is known about the potential risks and damages to the patient. Thus, attending carefully to the clinical complications arising as well as to security is essential.