Bone metastasis as the first symptom of tumors: role of an immunohistochemistry study in establishing primary tumor.

Objectives: To determine the role of immunohistochemistry in identifying the primary site of tumors, and in establishing which bones are most frequently involved, their relationship with the primary tumor site, and the rate of pathologic bone fracture as the first symptom of a malignant tumor.

Methods: A retrospective analysis of all medical records on bone metastases the cases treated between January 2006 and December 2011 at the Department of Orthopedics and Traumatology was performed.

Results: Immunohistochemistry correctly determined the primary tumor site in 61.

[A rare mediastinum tumor: hamartoma].

In the present paper we report a case of mediastinal tumor which we believe has never been reported. Since surgical treatment, the patient presented good evolution. We discuss the presentation, differential diagnosis and therapy.

Extramedullary nasal plasmacytoma: Literature review and a rare case report.

Introduction:  Extramedullary plasmacytoma is a plasma cell tumor that grows within any of the soft tissues of the organism. Similar to all plasmacytic dyscrasia, the disease is extremely rare.

Aim:  This study reports a case of an extramedullary plasmacytoma of the nasal cavity and provides a literature review on the topic.