Publications by authors named "Jose Cordero Ampuero"

Objectives: Treatment of subtrochanteric fractures of the proximal femur may be challenging due to their anatomical and biomechanical features. Intramedullary nails are the most frequently used devices, although there is no consensus concerning their optimal length. The aim of this study is to compare the functional and radiological outcomes of the fragility subtrochanteric fractures treated with short versus long cephalomedullary nails.

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  • The study compares the effectiveness of internal fixation (IF) and hemiarthroplasty (HA) in treating non-displaced femoral neck fractures in patients over 65, focusing on surgical aggression, mortality, complications, and walking recovery after one year.
  • Results indicate that IF leads to lower surgical aggression with shorter surgical times and less need for blood transfusion; however, HA has a significantly higher in-hospital mortality rate.
  • Overall, while there are no major differences in long-term mortality or medical complications between the two methods, specific surgical complications vary, with higher rates of dislocations and periprosthetic fractures in HA, and fixation failures in IF.
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Background: Few studies compare complications and results in ceramic-ceramic (CeCe) metal-on-crosslink polyethylene (Me-XLPE) hip prosthesis.

Methods: of 2 series of hydroxyapatite-coated Furlong Active implanted with identical protocol by 1 surgeon in 1 hospital from 2006 to 2014.

Bearing Surface: CeCe (Biolox Forte/Delta) in 35 cases of 53.

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  • The study aims to assess how surgical quality impacts mortality, complications, and the ability to walk in patients over 64 with hip fractures.
  • Conducted on 1,425 patients aged 65 to 108, the research analyzed various surgical methods and followed patients' recovery via clinical and radiographic evaluations.
  • Results indicated that poor surgical reduction significantly increased the risk of mortality and complications like non-unions and screw breakages.
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Aims: The aim of this study is to analyze the diagnostic value of weight-bearing radiographs, magnetic resonance images (MRI), and the combination of both in osteoarthritic knees when using arthroscopic findings as the "gold standard" to compare with.

Methods: A total of 59 patients were studied because of chronic pain in 1 of their knees. Radiographs were classified according to Kellgren-Lawrence scale.

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Background And Study Aim: Advanced therapy medicinal products (ATMP) frequently lack of clinical data on efficacy to substantiate a future clinical use. This study aims to evaluate the efficacy to heal long bone delayed unions and non-unions, as secondary objective of the EudraCT 2011-005441-13 clinical trial, through clinical and radiological bone consolidation at 3, 6 and 12 months of follow-up, with subgroup analysis of affected bone, gender, tobacco use, and time since the original fracture.

Patients And Methods: Twenty-eight patients were recruited and surgically treated with autologous bone marrow derived mesenchymal stromal cells expanded under Good Manufacturing Practices, combined to bioceramics in the surgical room before implantation.

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Spain is considered the healthiest nation in the world, due to lifepromoting aspects such as good diet, care facilities and a favourable family environment. However, although increased life expectancy is an indicator of development, it may have a negative impact on the other two variables of health service efficiency, namely health expenditure per capita and its relative weight in Gross Domestic Product.

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Unlabelled: The available scores to clinically evaluate fracture consolidation encounter difficulties to interpret progression towards consolidation in long-bone non-union, particularly when incorporating biomaterials in the surgical treatment. The aims of this study were to validate the REBORNE bone healing scale in tibia, humerus and femur non-unions treated by a combination of mesenchymal stromal cells (MSCs) and biomaterials, through the interclass correlation (ICC) among raters, and to define reliability and concordance in anteroposterior and lateral radiographs, compared to computed tomography (CT).

Methods: Twenty-six cases from the EudraCT 2011-005441-13 clinical trial underwent bone healing evaluation, if at least 3 out of 4 cortical views clearly identified.

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Prosthetic joint infection (PJI) is one of the most devastating complications in orthopedic surgery. One approach used to prevent PJI is local antibiotic therapy. This study evaluates the antibiotic release, in vitro cytocompatibility and in vivo effectiveness in preventing PJI caused by Staphylococcus aureus (S.

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Joint prosthesis failure is mainly related to aseptic loosening and prosthetic joint infections, both associated with high morbidity and a substantial cost burden for patients and health systems. The development of a biomaterial capable of stimulating bone growth while minimizing bacterial adhesion would reduce the incidence of prosthetic failure. Using an in vivo rabbit model, this study evaluates the osseointegration effect of the fluorine (F)- and phosphorus (P)-doped bottle-shaped nanostructured (bNT) Ti-6Al-4V alloy and effectiveness of monitoring urine aluminum concentration to determine the presence of infection in Ti-6Al-4V implants.

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Background: Bone remodelling with lateral femoral cortex thinning is a major concern after extensively porous-coated long-stem in revision surgery. Extensive hydroxyapatite coated long-stems were introduced to improve osseointegration, but bone remodelling changes have not been quantified.

Objective: The question of whether bone remodelling changes from extensive hydroxyapatite-coated long stems influence the durability of femoral revision, clinical outcome is assessed in follow-up radiographs.

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One-stage and two-stage revision strategies are the two main options for treating established chronic peri-prosthetic joint infection (PJI) of the hip; however, there is uncertainty regarding which is the best treatment option. We aimed to compare the risk of re-infection between the two revision strategies using pooled individual participant data (IPD). Observational cohort studies with PJI of the hip treated exclusively by one- or two-stage revision and reporting re-infection outcomes were retrieved by searching MEDLINE, EMBASE, Web of Science, The Cochrane Library, and the WHO International Clinical Trials Registry Platform; as well as email contact with investigators.

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Background: ORTHO-1 is a European, multicentric, first in human clinical trial to prove safety and feasibility after surgical implantation of commercially available biphasic calcium phosphate bioceramic granules associated during surgery with autologous mesenchymal stromal cells expanded from bone marrow (BM-hMSC) under good manufacturing practices, in patients with long bone pseudarthrosis.

Methods: Twenty-eight patients with femur, tibia or humerus diaphyseal or metaphyso-diaphyseal non-unions were recruited and surgically treated in France, Germany, Italy and Spain with 100 or 200 million BM-hMSC/mL associated with 5-10 cc of bioceramic granules. Patients were followed up during one year.

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Article Synopsis
  • ORTHOUNION is a randomized clinical trial comparing the effectiveness of autologous human bone marrow-derived stem cell (hBM-MSC) treatments versus iliac crest autograft (ICA) for improving bone healing in patients with nonunion fractures that have not healed for over nine months.
  • The trial will involve 108 participants who will be divided into three groups: one receiving a low dose of hBM-MSCs, another receiving a high dose, and a control group receiving ICA, all monitored for one to two years.
  • The main goal is to see if hBM-MSCs combined with biomaterials lead to better bone healing compared to ICA, with a secondary goal of determining if a lower dose (100 
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An in vitro study aimed to evaluate the effect of N-acetyl cysteine (NAC) or sub-ICs of erythromycin on antimicrobial susceptibility of staphylococcal biofilms was performed. Staphylococcus aureus and Staphylococcus epidermidis strains were isolated from patients with prosthetic joint infections using a previously published sonication procedure. Conventional susceptibility studies were performed using microdilution according to the CLSI procedures.

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  • The study investigates the prevalence and impact of preoperative asymptomatic bacteriuria in patients undergoing knee arthroplasty, focusing on the risk of prosthetic joint infection and the effectiveness of antibiotic treatment.
  • Out of 215 patients, only 5.1% were diagnosed with asymptomatic bacteriuria, all of whom were female; four received antibiotics while the rest did not.
  • The results showed a very low incidence of infection (0.5%) in the group receiving antibiotics, with no infections found in those not treated, suggesting that asymptomatic bacteriuria may not significantly increase the risk of infection post-surgery.
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  • * Using data from hip procedures between 1997 and 2011, the analysis revealed that while there are significant regional differences in primary and revision total hip replacements (THR), these disparities occur despite Spain's universal healthcare system.
  • * The findings indicated that although the ageing index, regional health budget, and density of surgeons contribute to understanding these variations, they only partially account for the differences in hip replacement rates after adjustments for demographics.
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  • The study investigates short-term radiographic subsidence of Furlong Active HAP stems in hip replacements, examining factors like age, gender, and bone quality.
  • A total of 65 patients were followed for an average of nearly 3 years, showing an average subsidence of 2.4 mm in the stems, with 61% experiencing subsidence upon weight bearing.
  • Results indicated higher subsidence rates in males, but no significant correlations were found with other examined factors like age or bone morphology.
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Synopsis of recent research by authors named "Jose Cordero Ampuero"

  • - Jose Cordero Ampuero's research focuses on orthopedic trauma surgery, particularly in evaluating the effectiveness of materials and surgical techniques in hip and long bone treatments.
  • - His studies include investigating complications in ceramic-on-ceramic hip prosthetics, the survivability of infected implants, and the influence of surgical quality on recovery rates in hip fracture patients.
  • - Additionally, he explores advanced therapies like mesenchymal stromal cells combined with biomaterials for treating non-unions, as well as innovative approaches to preventing prosthetic joint infections through enhanced material properties.