Publications by authors named "Jose Chinchilla"
Purpose: The main objective was to characterize the tracer uptake kinetics of [F]fluoromethylcholine ([F]F-CHO) in high-grade gliomas (HGG) through a full PET kinetic modeling approach. Secondarily, we aimed to explore the relationship between the PET uptake measures and the HGG molecular features.
Materials And Methods: Twenty-four patients with a suspected diagnosis of HGG were prospectively included.
Article Synopsis
- Glyphosate is the most commonly used herbicide globally, but its analysis is complicated due to its small and polar nature; a new LC-HRMS/MS method was created to effectively detect it in the gastric content of Iberian hares.
- The validation of this method showed high accuracy and precision, with glyphosate levels in hare samples from pesticide-treated areas found to be between 9-22%, and even 45% in animals that died in the wild.
- This research offers a reliable way to assess glyphosate exposure in wildlife, highlighting the presence of the pesticide in areas where it is used and ensuring safer ecological practices.
Introduction: After its intravenous injection, [F]fluorocholine is oxidized by choline-oxidase into its main plasma metabolite, [F]fluorobetaine. If PET kinetic modeling quantification of [F]fluorocholine uptake is intended, the plasma input time-activity-curve of the parent tracer must be obtained, i.e.
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