Partially dissociable roles of the orbitofrontal cortex and dorsal hippocampus in context-dependent hierarchical associations.

Reward cues are often ambiguous; what is good in one context is not necessarily good in another. To solve this ambiguity, animals form hierarchical associations in which the context gates the retrieval of appropriate cue-evoked memories. These hierarchical associations regulate cue-elicited behavior and influence subsequent learning, promoting the inference of context-dependency.

Sex differences in discrimination behavior and orbitofrontal engagement during context-gated reward prediction.

Animals, including humans, rely on contextual information to interpret ambiguous stimuli. Impaired context processing is a hallmark of several neuropsychiatric disorders, including schizophrenia, autism spectrum disorders, post-traumatic stress disorder, and addiction. While sex differences in the prevalence and manifestations of these disorders are well established, potential sex differences in context processing remain uncertain.

A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation.

Ataxia Telangiectasia (A-T) and Ataxia with Ocular Apraxia Type 1 (AOA1) are devastating neurological disorders caused by null mutations in the genome stability genes, A-T mutated () and Aprataxin (), respectively. Our mechanistic understanding and therapeutic repertoire for treating these disorders are severely lacking, in large part due to the failure of prior animal models with similar null mutations to recapitulate the characteristic loss of motor coordination (i.e.