Prevention of brain protein and lipid oxidation elicited by a water-soluble oryzanol enzymatic extract derived from rice bran.

Background: The antioxidant capacity of rice bran (RB) (due mainly to its gamma-oryzanol content) is very well known. We have recently developed a water-soluble oryzanol enzymatic extract (WSOEE), which shows a greatly increased functionality.

Aim Of The Study: The aim of our study is the evaluation of the antioxidant potential of WSOEE in an ex vivo model to compare its protective capacity against oxidative damage by active-oxygen substances and free radicals (mainly the peroxyl radical) to biomolecules (such as proteins and lipids) with that of antioxidants, such as Trolox (a water-soluble derivative of vitamin E), melatonin, and folic acid.