Simvastatin modulates gingival cytokine and MMP production in a rat model of ligature-induced periodontitis.

Purpose: The aim of this study was to evaluate the effect of simvastatin on the synthesis of cytokines TNF-α and IL-10 and metalloproteinase (MMPs) 2 and 9 in a rat model of ligature-induced periodontitis.

Materials And Methods: Twenty Wistar rats were used, and a cotton ligature was place in a subgingival position encircling the entire cervix of the first molar of the left (ipsilateral) side of the mandible. The right (contralateral) side of the mandible had no ligature placed and was used as control.

Effectiveness of Oral Antiseptics on Tooth Biofilm: A Study in vivo.

Aim: To evaluate the effectiveness of five different mouthwashes through measurement of the plaque index.

Materials And Methods: Fifty subjects took part in this blind study, randomized into blocks of five groups according to the active ingredient of the mouthwash: CHX group (0.12% chlorhexidine gluconate), essential oils (EO) group, cetylpyridinium chloride (CPC) group, Tri group (triclosan) and Hamamelis virginiana (HV) group.