Publications by Jose Bustamante-Salazar

Publications by authors named "Jose Bustamante-Salazar"

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New Molecular and Organelle Alterations Linked to Down Syndrome Heart Disease.

Leslye Venegas-Zamora Francisco Bravo-Acuña Francisco Sigcho Wileidy Gomez José Bustamante-Salazar

Front Genet

January 2022

Down syndrome (DS) is a genetic disorder caused by a trisomy of the human chromosome 21 (Hsa21). Overexpression of Hsa21 genes that encode proteins and non-coding RNAs (ncRNAs) can disrupt several cellular functions and biological processes, especially in the heart. Congenital heart defects (CHDs) are present in 45-50% of individuals with DS.

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