Publications by authors named "Jose Bianco N Moreira"
Background: Microglia and inflammation play a significant role in Alzheimer's disease (AD). Physical exercise and peripheral signals can influence microglial activity in the brain. Modulating the inflammatory response in the brain may provide therapeutic approaches for AD.
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- Exercise training has positive effects on brain health, potentially protecting against cognitive decline and Alzheimer's disease, possibly through blood factors.
- In experiments, plasma from exercise-trained individuals improved neuronal health in cells exposed to Alzheimer's-related stress and increased neurogenesis in rats without altering cognitive function or amyloid plaque levels.
- The study suggests that these protective effects may be due to lower levels of certain inflammatory molecules in the blood of those who exercise regularly.
Alzheimer's disease (AD) is the most common cause of dementia and there is currently no cure. Novel approaches to treat AD and curb the rapidly increasing worldwide prevalence and costs of dementia are needed. Physical inactivity is a significant modifiable risk factor for AD, estimated to contribute to 12.
View Article and Find Full Text PDFTo date there is no cure available for dementia, and the field calls for novel therapeutic targets. A rapidly growing body of literature suggests that regular endurance training and high cardiorespiratory fitness attenuate cognitive impairment and reduce dementia risk. Such benefits have recently been linked to systemic neurotrophic factors induced by exercise.
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