Antiprotozoal Activities of Tiliroside and other Compounds from (Cav.) G. Don.

Background: (Malvaceae) is extensively used in Mexican traditional medicine for the treatment of gastrointestinal disorders such as diarrhea and dysentery.

Objective: The current study was to validate the traditional use of for the treatment of diarrhea and dysentery on biological grounds using antiprotozoal activity and computational experiments.

Materials And Methods: The ethanol extract, subsequent fractions, flavonoids, phenolic acids, and a sterol were evaluated on and trophozoites.

Current Tools and Methods in Molecular Dynamics (MD) Simulations for Drug Design.

Molecular Dynamics (MD) simulations is a computational method that employs Newton's laws to evaluate the motions of water, ions, small molecules, and macromolecules or more complex systems, for example, whole viruses, to reproduce the behavior of the biological environment, including water molecules and lipid membranes. Specifically, structural motions, such as those that are dependent of the temperature and solute/ solvent are very important to study the recognition pattern of ligandprotein or protein-protein complexes, in that sense, MD simulations are very useful because these motions can be modeled using this methodology. Furthermore, MD simulations for drug design provide insights into the structural cavities required to design novel structures with higher affinity to the target.

Multiple Local Recurrent Myxoma.

Cardiac myxomas, usually considered benign tumors, occasionally pursue an aggressive clinical course. The recurrence of sporadic myxomas is much less frequent than that of complex or familial myxomas (1-3% vs. 22% vs.