New-onset diabetes after kidney transplantation: Assessing urinary Wilm's tumor-1 protein to predict renal allograft dysfunction.

Purpose: New-onset diabetes after transplantation (NODAT) is a frequent metabolic complication associated with podocyte damage and renal allograft dysfunction. Thus, Wilm's tumor-1 (WT-1) protein, as a podocyte marker, holds promise as an option to evaluate renal allograft dysfunction in NODAT. Therefore, the study aimed to investigate urinary WT-1 levels in NODAT patients during the first year after kidney transplantation (KTx).

Direct oral anticoagulants versus vitamin K antagonists in patients with atrial fibrillation and stage 5 chronic kidney disease under dialysis: A systematic review and meta-analysis of randomized controlled trials.

Background: In patients with atrial fibrillation (AF) and normal or slightly impaired renal function, the use of direct oral anticoagulants (DOACs) is preferable to vitamin K antagonists (VKAs). However, in patients undergoing hemodialysis, the efficacy, and safety of DOACs compared with VKAs are still unknown.

Purpose: To review current evidence about the safety and efficacy of DOACs compared to VKAs, in patients with AF and chronic kidney disease under hemodialysis.

Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study.

Introduction: Low 25-hydroxyvitamin D [25(OH)D] levels occur after kidney transplantation (KTx), and can be associated with increase the risk of graft loss. This longitudinal study aimed to evaluate the vitamin D status and association with biomarkers of the renal graft function after KTx. Methods: this longitudinal study included 42 patients evaluated at baseline, 3 and 6 months after KTx.

Effects of an individualized nutritional intervention on kidney function, body composition, and quality of life in kidney transplant recipients: Study protocol for a randomized clinical trial.

Background: Proteinuria after kidney transplantation (KTx) has been a frequent problem due to several factors, high protein intake being one of them. Individualized nutritional intervention in the late post-KTx period can promote the improvement or the reduction of risks associated with the parameters of evaluation of kidney function, body composition, and quality of life in individuals submitted to KTx.

Methods: This is a single-center, randomized and stratified clinical trial.

Measuring eosinophiluria, urinary eosinophil cationic protein and urinary interleukin-5 in patients with Lupus Nephritis.

Background: Urine is increasingly becoming an attractive biological fluid in clinical practice due to being an easily obtained, non-invasive sampling method, containing proteins and peptides. The aim of this study was to investigate eosinophiluria, urinary eosinophil cationic protein (uECP) and urinary IL-5 (uIL-5) in patients with Lupus Nephritis.

Methods: Seventy-four patients with SLE-20 with clinical and laboratory evidence of lupus nephritis (LN group) and 54 without evidence of renal involvement (non-LN group)-were analyzed regarding eosinophiluria, uECP and uIL-5.

Technique for a single-time correction of arteriovenous fistula aneurysm in conjuction with creation of a new venous drainage pathway.

Aneurysm and stenosis are among the most frequent complications of an arteriovenous fistula (AVF) for hemodialysis. The occurrence of the two kinds of problem may be found in one and the same patient, affecting the use of the AVF and even rendering its use impossible. We report the technique used for correction of a patient's aneurysmal dilations of radio-cephalic AVF and stenosis after the aneurysmal segment, with an increase in post-punction bleeding during the hemodialysis sessions.

Pseudotumor cerebri associated with cyclosporin use following renal transplantation.

Pseudotumor cerebri (PC) is a syndrome characterized by the presence of intracranial hypertension (ICH) and no alteration in the ventricular system. Renal transplanted patients seem more susceptible to develop it due to immunosuppressive therapy. Cyclosporin (CsA) is a rare cause of PC, scarcely reported in the literature, and should be considered in the differential diagnosis of ICH and papilledema in those patients.

Presence of antibodies against Leishmania chagasi in haemodialysed patients.

In the last decades there has been an increase in cases of visceral leishmaniasis complicating the post-transplant phase, mainly following kidney transplantation. The aim of this study was to evaluate the reactivity of haemodialysed patients using IFAT. Blood samples of 310 individuals from Natal, RN, Brazil, were collected and analysed.

Binocular vision changes in university students: a 3-year longitudinal study.

Purpose: The aim of this study was to investigate the changes in accommodation and binocular vision parameters during a period of 3 years and to evaluate their potential influence on the refractive changes observed over the same period of time in a population of university students in Portugal.

Methods: A 3-year longitudinal study was conducted comprising 118 young adults (34 males and 84 females; mean age: 20.6 +/- 2.

External factors affecting data acquisition during corneal topography examination.

Purpose: To analyze the factors affecting data acquisition during corneal topography examination with the Medmont E-300 videokeratoscope and to provide strategies to minimize their effects.

Methods: Sixty eyes from thirty young adults were examined. A second observer registered incidences with the potential to affect data acquisition.

Contact lens fitting profile in Portugal in 2005: strategies for first fits and refits.

Purpose: To evaluate the standards of contact lens practice in Portugal, with particular attention paid to the characteristics of first fits and refits regarding aspects such as symptoms of dryness, overnight wear, silicone hydrogel and multifocal prescriptions, and care systems.

Methods: A questionnaire was distributed to 300 contact lens practitioners in Portugal, and they were asked to complete them with the following first 10 fittings (only right eye of each patient). Fifty-six questionnaires were returned to total 529 fittings.

Qualitative and quantitative characterization of the in vitro dehydration process of hydrogel contact lenses.

Purpose: To investigate the in vitro dehydration process of conventional hydrogel and silicone-hydrogel contact lens materials.

Methods: Eight conventional hydrogel and five silicone-hydrogel contact lenses were dehydrated under controlled environmental conditions on an analytical balance. Data were taken at 1-min intervals and dehydration curves of cumulative dehydration (CD), valid dehydration (VD), and dehydration rate (DR) were obtained.

Symptoms in a population of contact lens and noncontact lens wearers under different environmental conditions.

Purpose: To investigate ocular symptoms related to dryness in an adult population of contact lens (CL) and non contact lens wearers (n-CL) using video display terminals (VDT) for different periods of time under different indoor conditions related to air conditioning (AC) and heating units (HU) exposure.

Methods: A questionnaire was distributed to 334 people within a university population of which 258 were part of the n-CL group and 76 of the CL wearers to assess symptoms of ocular discomfort potentially related to dryness. Only soft contact lens (SCL) wearers (n = 71) were included for further statistical analysis because of the reduced number of people wearing other lens types.

Effect of end-stage renal disease and diabetes on zinc and copper status.

The aim of this study was to compare the nutritional status of zinc and copper in patients with and without diabetes submitted to chronic hemodialysis. Thirty-three patients with type 2 diabetes (DM group), 30 nondiabetic patients (NDM group), and 20 healthy individuals (control group) were studied. Plasma, erythrocyte, and urinary zinc and plasma copper were obtained from atomic absorption spectrophotometry and ceruloplasmin by immunonephelometry.

Correlations between central and peripheral changes in anterior corneal topography after myopic LASIK and their implications in postsurgical contact lens fitting.

Purpose: To investigate the changes in central and peripheral anterior corneal curvatures after myopic laser in situ keratomileusis (LASIK) and to correlate them with the manifest refractive change to discuss how such results could affect post-LASIK corneal topography profiles and midterm stability and their implications in postsurgical contact lens fitting.

Methods: Topographic and refractive data from 18 eyes of 11 patients that had undergone myopic LASIK were collected for 6 months after surgery. Short-term and midterm topographic responses were investigated and correlated with spherical equivalent manifest refractive changes.

Soft contact lenses for keratoconus: case report.

Purpose: Contact lenses have assisted the refractive correction of keratoconus since the 19th century. In these case reports, the authors describe their experience with a new soft contact lens design.

Methods: The Soft K is a new soft lens comprising a thick fenestrated design to fit in patients with mild to moderate corneal distortion and fitting problems or physical intolerance to rigid gas-permeable (RGP) contact lenses.

Equivalences between refractive index and equilibrium water content of conventional and silicone hydrogel soft contact lenses from automated and manual refractometry.

Purpose: The purpose of the present study was to develop mathematical relationships that allow obtaining equilibrium water content and refractive index of conventional and silicone hydrogel soft contact lenses from refractive index measures obtained with automated refractometry or equilibrium water content measures derived from manual refractometry, respectively.

Methods: Twelve HEMA-based hydrogels of different hydration and four siloxane-based polymers were assayed. A manual refractometer and a digital refractometer were used.

Refractive index and equilibrium water content of conventional and silicone hydrogel contact lenses.

Purpose: The purpose of the present study was to measure equilibrium water content (EWC) and refractive index of conventional and silicone hydrogel soft contact lenses (SCL) using a hand refractometer and an automated refractometer.

Methods: Sixteen SCL were used in this study including 12 conventional SCL not containing siloxane moieties (equilibrium water content (EWC) range: 38.6-74%) and the four silicone hydrogel based contact lenses currently available (WC range: 24-47%).

Oxygen transmissibility of piggyback systems with conventional soft and silicone hydrogel contact lenses.

Purpose: To investigate the apparent oxygen transmissibility of various piggyback systems using conventional and silicone hydrogel soft contact lenses of different water content and permeability, rigid poly(methyl methacrylate), and rigid gas-permeable lenses of medium, high, and ultrahigh oxygen permeability. The aim of the study was to establish which material (rigid or hydrogel) is more representative of the resulting oxygen performance of piggyback systems.

Methods: The apparent oxygen transmissibility of 66 piggyback systems was measured with an electrochemical method.

Microscopic observation of unworn siloxane-hydrogel soft contact lenses by atomic force microscopy.

In the present study, samples of lotrafilcon A, balafilcon A, and galyfilcon A contact lenses were observed by atomic force microscopy (AFM) in tapping mode at areas ranging from 0.25 to 400 microm2. Mean roughness (Ra), root-mean-square roughness (Rms) and maximum roughness (Rmax) in nanometers were obtained for the three lens materials at different magnifications.

Microscopic observations of superficial ultrastructure of unworn siloxane-hydrogel contact lenses by cryo-scanning electron microscopy.

The purpose of this study was to analyze three commercial siloxane-hydrogel contact lens materials, lotrafilcon A, balafilcon A, and galyfilcon A, by cryogenic scanning electron microscopy (cryoSEM). The fully hydrated lenses were frozen in slush liquid nitrogen and qualitatively observed in a cryogenic scanning electron microscope. The superficial ultrastructure of the siloxane-hydrogels was observed at the areas where the lens fractured during sample cryogenic preparation.

Retinoscopy/autorefraction: which is the best starting point for a noncycloplegic refraction?

Purpose: The aim of this study was to estimate the agreement between an autorefractor (Nidek ARK 700A, Gamagori, Japan) and retinoscopy with subjective refraction.

Methods: Measurements of autorefraction obtained with the ARK700A and retinoscopy were performed on 192 right eyes from 192 healthy young adults and compared with subjective refraction. These measurements were performed without cycloplegia.