Publications by authors named "Jose Arimatea de Oliveira Nery-Neto"
Article Synopsis
- Macrophages play a crucial role in regulating the immune response both in normal conditions and during inflammation, and sitagliptin, a diabetes drug, has shown potential anti-inflammatory effects.
- This study investigated how sitagliptin affects macrophage polarization, finding that it enhances the M2 macrophage phenotype while reducing pro-inflammatory markers like TNF-α.
- Additionally, sitagliptin treatment impacted mitochondrial function in M2 macrophages, leading to lower energy production and reduced ability to engulf particles.
Article Synopsis
- Recent studies show that problems in your gut, like infections or changes in gut bacteria, can relate to kidney diseases.
- *Some genes that affect kidney issues also relate to gut problems, suggesting they are connected.
- *Certain cells in the gut, called enteroendocrine cells, produce hormones that can help protect the kidneys, and understanding these could lead to better kidney treatments.
Isopropyl gallate (IPG) is a polyphenol obtained from alterations in the gallic acid molecule via acid catalysis with previously reported leishmanicidal and trypanocidal activities. The present study aims to evaluate in silico binding activity towards some targets for antileishmanial chemotherapy against species, and ADMET parameters for IPG, as well as in vitro antileishmanial and cytotoxic effects. Molecular docking was performed using AutoDockVina and BIOVIA Discovery Studio software, whereas in silico analysis used SwissADME, and admetSAR software.
View Article and Find Full Text PDF