Formalization of gene regulation knowledge using ontologies and gene ontology causal activity models.

Gene regulation computational research requires handling and integrating large amounts of heterogeneous data. The Gene Ontology has demonstrated that ontologies play a fundamental role in biological data interoperability and integration. Ontologies help to express data and knowledge in a machine processable way, which enables complex querying and advanced exploitation of distributed data.

EHR problem list clustering for improved topic-space navigation.

Background: The amount of patient-related information within clinical information systems accumulates over time, especially in cases where patients suffer from chronic diseases with many hospitalizations and consultations. The diagnosis or problem list is an important feature of the electronic health record, which provides a dynamic account of a patient's current illness and past history. In the case of an Austrian hospital network, problem list entries are limited to fifty characters and are potentially linked to ICD-10.

Supervised ICD Code Assignment to Short Clinical Problem List Entries.

Clinical information systems contain free-text entries in different contexts to be used in a variety of application scenarios. In this study we investigate to what extent diagnosis codes using the disease classification system ICD-10 can be automatically post-assigned to patient-based short problem list entries, (50 characters maximum). Classifiers using random forest and Adaboost performed best with an F-measure of 0.

EHR Text Categorization for Enhanced Patient-Based Document Navigation.

Patients with multiple disorders usually have long diagnosis lists, constitute by ICD-10 codes together with individual free-text descriptions. These text snippets are produced by overwriting standardized ICD-Code topics by the physicians at the point of care. They provide highly compact expert descriptions within a 50-character long text field frequently not assigned to a specific ICD-10 code.