Early- versus late-onset systemic sclerosis: differences in clinical presentation and outcome in 1037 patients.

Peak age at onset of systemic sclerosis (SSc) is between 20 and 50 years, although SSc is also described in both young and elderly patients. We conducted the present study to determine if age at disease onset modulates the clinical characteristics and outcome of SSc patients. The Spanish Scleroderma Study Group recruited 1037 patients with a mean follow-up of 5.

Proton pump inhibitors in gastroesophageal reflux disease: "a custom-tailored therapeutic regimen".

The Montreal Definition and Classification divides Gastroesophageal Reflux Disease (GERD) into esophageal symptomatic syndromes (and with mucosal damage) and extraesophageal syndromes (with acid established association and proposed association). In typical GERD symptoms, an 8-week treatment with PPIs is satisfactory in most cases (> 90%). Response rates to PPIs in GERD are highly variable, as they also rely on an appropriate clinical diagnosis of the disease; endoscopy differentiates the macroscopic GERD phenotype.

Effect of body weight and esophageal damage on the severity of gastroesophageal reflux symptoms. Mexican GERD working group.

Background And Aims: Several studies have demonstrated overweight and obesity are strong independent risk factors of GERD symptoms and esophageal erosions. Our aim was to analyze the joint effect of BMI with the grade of esophageal damage over symptoms' intensity of GERD.

Methods: We used a questionnaire with a Likert scale for severity of symptoms related to GERD.

[Patients with type III obesity given sibutramine 15 mg/day lose weight in amounts proportional to those in types I and II, but waist circumferences does not decrease proportionally].

Objective: The etiology, comorbidity, metabolism, and treatment response vary among overweight and obesity types I, II and III individuals. We assessed the association between obesity type with body mass index, waist circumference and tolerance to a daily dose of 15 mg of sibutramine.

Materials And Methods: A sample of 701 individuals recruited from 47 health centers was analyzed.

Results of the national survey of borderline ovarian tumors in Spain.

Material And Methods: Retrospective multi-center analysis of women diagnosed with borderline ovarian tumor and treated between January 1990 and December 1997. A national survey was conducted, in which 457 patients from 27 centers corresponding to ten of Spain's autonomous communities were analyzed.

Results: Four hundred fifty-seven women with borderline ovarian tumor were analyzed.

[Is endoscopy necessary to initiate medical treatment in primary-level medical care patients with not investigated dyspepsia?].

Introduction: Approximately 2 to 5% of primary care consultations are patients with dyspepsia. One of the most controversial points among primary-care physicians and gastroenterologists is the diagnostic-therapeutic approach of the uninvestigated dyspeptic patient.

Aims And Methods: Our aim was to investigate prevalence of organic disease and Helicobacter pylori (Hp) status in uninvestigated dyspeptic out-patients at a primary-care level.