Publications by authors named "Jose Antonio Lojo"
Article Synopsis
- The dual syndrome hypothesis in Parkinson's disease (PD) divides cognitive impairment into two types: one related to dopamine affecting executive function and another linked to the cortex that leads to dementia.
- The study examined several genes (APOE, MAPT, COMT, SNCA, and GBA) in 298 PD patients to see how they contribute to these syndromes, finding that certain gene variants like APOE2, SNCA 'G', and GBA negatively impact dopamine levels, while others like COMT has a positive effect.
- Additionally, the APOE4 variant and GBA variants were associated with increased risk of developing dementia, indicating that genetic factors play a significant role in the cognitive decline seen in PD patients.
Parkinson's disease (PD) patients who present with tremor and maintain a predominance of tremor have a better prognosis. Similarly, PD patients with high levels of uric acid (UA), a natural neuroprotectant, have also a better disease course. Our aim was to investigate whether PD motor subtypes differ in their levels of UA, and if these differences correlate with the degree of dopamine transporter (DAT) availability.
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