Publications by authors named "Jose Antonio Hermo"
Objectives: PTEN hamartoma tumor syndrome (PHTS) is a hereditary disorder caused by germline inactivating mutations of the PTEN gene. PHTS includes Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome. We describe how the peculiar pathologic and immunohistochemical thyroid features lead pathologists to suggest PHTS.
View Article and Find Full Text PDFDiagnostic accuracy of fecal immunochemical test in average- and familial-risk colorectal cancer screening.
United European Gastroenterol J
December 2014
Background: There is little information about the fecal immunochemical test (FIT) in familial-risk colorectal cancer (CRC) screening.
Objectives: The objective of this article is to investigate whether FIT diagnostic accuracy for advanced neoplasia (AN) differs between average and familial-risk (first-degree relative) patients.
Methods: A total of 1317 consecutive participants (595 familial) who collected one stool sample before performing a colonoscopy as a CRC screening test were included.
Article Synopsis
- The study investigates the effectiveness of fecal immunochemical tests (FIT) versus sigmoidoscopy in detecting advanced right-sided colorectal neoplasia.
- Results show that while FIT is more specific, it has lower sensitivity compared to sigmoidoscopy according to certain criteria.
- Combining FIT with sigmoidoscopy increases detection rates but reduces specificity, highlighting limitations in current screening methods for this type of cancer.
Characteristics of adenomas detected by fecal immunochemical test in colorectal cancer screening.
Cancer Epidemiol Biomarkers Prev
September 2014
Background: Fecal immunochemical test (FIT) diagnostic accuracy for colorectal adenoma detection in colorectal cancer screening is limited.
Methods: We analyzed 474 asymptomatic subjects with adenomas detected on colonoscopy in two blinded diagnostic tests studies designed to assess FIT diagnostic accuracy. We determined the characteristics of adenomas (number, size, histology, morphology, and location) and the risk of metachronous lesions (according to European guidelines).
Aim: To assess the fecal immunochemical test (FIT) accuracy for colorectal cancer (CRC) and advanced neoplasia (AN) detection in CRC screening.
Methods: We performed a multicentric, prospective, double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy. Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample (FIT1) and the highest level of both samples (FITmax) using the OC-sensor™.