Publications by authors named "Jose Antonio Calera"

Synopsis of recent research by authors named "Jose Antonio Calera"

  • - Jose Antonio Calera’s research primarily focuses on the mechanisms of zinc metabolism in Aspergillus fumigatus, exploring how this opportunistic pathogen regulates zinc homeostasis to thrive in zinc-limited host environments, which is crucial for its virulence.
  • - Recent studies highlighted include the role of the ZafA transcription factor in zinc uptake and its interaction with other elements like environmental pH and iron, suggesting that the regulation of zinc homeostasis is complex and vital for the organism's survival and pathogenicity.
  • - Calera has also investigated the potential of zinc-targeting compounds as therapeutic strategies against fungal infections, demonstrating that zinc chelators can enhance treatment efficacy and survival rates in infected individuals, thereby presenting new avenues for antifungal drug development.