Publications by authors named "Jose Alberto Neder"
Effects of Home-Based Electrical Stimulation on Plasma Cytokines Profile, Redox Biomarkers, and Metalloproteinases in the Heart Failure with Reduced Ejection Fraction: A Randomized Trial.
J Cardiovasc Dev Dis
December 2022
Article Synopsis
- Low-frequency electrical stimulation (LFES) is explored as an alternative for heart failure (HF) patients struggling to exercise, focusing on its effects over 10 weeks on various biomarkers and exercise performance.
- In a study with 24 HF patients, LFES increased active-MMP2 levels while decreasing active-MMP9 levels, indicating some biochemical changes, but did not affect cytokines, redox biomarkers, or overall exercise performance significantly.
- The findings suggest that LFES may help modulate MMP activity, which could support muscle adaptation for future physical demands, although the overall functional benefits appear limited.
Objective: Impaired respiratory mechanics and gas exchange may contribute to sleep disturbance in patients with COPD. We aimed to assess putative associations of different domains of lung function (airflow limitation, lung volumes, and gas exchange efficiency) with polysomnography (PSG)-derived parameters of sleep quality and architecture in COPD.
Methods: We retrospectively assessed data from COPD 181 patients ≥ 40 years of age who underwent spirometry, plethysmography, and overnight PSG.
Background: Exercise-induced hypoxaemia is a hallmark of chronic fibrotic interstitial lung disease (-ILD). It remains unclear whether patients' severe hypoxaemia may exaggerate locomotor muscle fatigue and, if so, to what extent oxygen (O) supplementation can ameliorate these abnormalities.
Methods: Fifteen patients (12 males, 9 with idiopathic pulmonary fibrosis) performed a constant-load (60% peak work rate) cycle test to symptom limitation (Tlim) while breathing medical air.