Vasomotor response to different endothelium-dependent vasodilators in an animal model.

Background And Objectives: Incomplete re-endothelialization of stents can be revealed as paradoxical vasoconstriction with endothelium-dependent vasodilators. As no consensus exists about the best method or agent, our objective is to analyze the response to different drugs in a coronary swine model.

Methods: Twenty-seven stents were implanted in 9 domestic swine.

[Instent restenosis related to vessel injury score degree. Are current experimental models valid for drug-eluting stents analysis?].

Introduction And Objectives: Drug-eluting stents are useful for preventing restenosis, but the patho-physiological processes involved in the proliferative response after implantation are still not known in detail. The aim of this study is to compare the coronary vascular histomorphometry after implanting drug-eluting stents and bare metal stents in a swine model.

Methods: Sixty stents were randomly implanted in 20 Large White female pigs with a ratio of baremetal/drug-eluting stents of 1:2.