Publications by authors named "Jose Agustin Lopez"
Article Synopsis
- Infection by certain rotavirus strains relies on sialic acid on cell surfaces, and reducing sialic acid through neuraminidase treatment lowers infectivity.
- A neuraminidase-resistant mutant of the porcine rotavirus strain OSU was identified, with a key mutation in its VP4 protein, changing Asp to Asn at position 100, which allows it to still bind to sialic acid.
- This mutation is linked to the strain's ability to evade neutralization by specific monoclonal antibodies and can be countered by a compensatory mutation at position 125, demonstrating dynamic structural changes in response to sialic acid binding.
