Multimorbidity patterns in dementia and mild cognitive impairment.

Design: This is a retrospective cohort study. Setting: The study was conducted at the Instituto de Neurociencias de la Junta de Beneficencia de Guayaquil, a primary neuroscience institute in Ecuador.

Participants: The study evaluated 425 participants diagnosed with Mild Cognitive Impairment (MCI) or dementia, out of which 272 individuals (mean age = 75 years; 164 female) presenting specific medical conditions were selected for analysis.

Spanish Validation Of The Revised Depression Attitude Questionnaire (R-DAQ).

Purpose: The aim of the study was to develop and validate a Spanish version of the Revised Depression Attitude Questionnaire (R-DAQ).

Methods: The R-DAQ was used as a baseline for the study. It was translated and tested to ensure the instrument was appropriate for the target population.

De novo mutations in ataxin-2 gene and ALS risk.

Pathogenic CAG repeat expansion in the ataxin-2 gene (ATXN2) is the genetic cause of spinocerebellar ataxia type 2 (SCA2). Recently, it has been associated with Parkinsonism and increased genetic risk for amyotrophic lateral sclerosis (ALS). Here we report the association of de novo mutations in ATXN2 with autosomal dominant ALS.