Publications by authors named "Jos van der Stappen"
The increased usage of alternative Ayurvedic treatments as potential health-beneficial therapies emphasizes the importance of studying its efficacy in sound placebo-controlled intervention trials. An example of such a traditional Ayurvedic herbal preparation is Mohana Choorna, a mixture composed of 20 different herbs and used to prevent and treat type 2-diabetes (T2D). We studied the efficacy of "Mohana Choorna" on T2D-related parameters in subjects with impaired glucose tolerance.
View Article and Find Full Text PDFBackground: In populations with mild iodine deficiency, the serum level of thyrotropin (TSH) is negatively and the serum free thyroxine (FT4) is positively associated with age. An ongoing decrease of TSH and increase of FT4 can be found after iodine supplementation. The aim of this study was to investigate whether there are current differences in the relation between thyroid function and age in relation to differences in iodine intake in the past.
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- GI cancer is a leading cause of cancer-related deaths, with lifestyle factors and reactive oxygen species (ROS) believed to play significant roles in its development.
- This study evaluated the impact of specific genetic variations (SNPs) in the NQO1 gene on GI cancer risk among 1457 Dutch patients and controls, using real-time PCR for genetic analysis.
- The findings showed no overall significant differences in the SNP genotype distributions between patients and controls; however, the rs1800566 CT genotype was linked to an increased risk for proximal colon cancer.
Introduction: Circulating plasma DNA is present in a considerably higher concentration in lung cancer patients than in controls. Conflicting data are reported about circulating DNA as a prognostic factor. The aim of this study was to prospectively analyse the relationship of circulating plasma DNA with overall survival (OS) of previously untreated non-small cell lung cancer (NSCLC) patients.
View Article and Find Full Text PDFBackground: Genetic predisposition to hemochromatosis involves several different point mutations in the HFE gene. Routine testing for two such mutations (H63D and S65C) using real-time genotyping deserves special care, as these mutations are in close proximity (6 bp) of each other.
Methods: A novel assay was designed for these two mutations based on a SimpleProbe assay format that allows for more flexibility in assay design, as it requires only one detection probe instead of the two probes that are commonly used with a hybridization probe based assay.