The prognostic potential of mammographic growth rate of invasive breast cancer in the Nijmegen breast cancer screening cohort.

Objectives: Insight into the aggressiveness of potential breast cancers found in screening may optimize recall decisions. Specific growth rate (SGR), measured on mammograms, may provide valuable prognostic information. This study addresses the association of SGR with prognostic factors and overall survival in patients with invasive carcinoma of no special type (NST) from a screened population.

The impact of histological subtype in developing both ovarian and endometrial cancer: A longstanding nationwide incidence study.

Objectives: To estimate the incidence of ovarian cancer (OC) and endometrial cancer (EC) separately, as well as double cancers diagnosed in the same calendar year, and to relate the occurrences to histological subtype.

Study Design: All cases of epithelial OC and EC diagnosed in the Netherlands in 1989-2009 were related to population data. Histologically specific associations were made using the ratio of observed and expected incidence numbers, calculated with age-specific incidence rates.

[Predicting chance of disease: calculation using prediction rules].

A prediction rule is a statistical model that can be used to predict the presence or absence of a disease based on a limited number of tests or predictive factors. One of the mathematical methods used to formulate prediction rules is a logistic regression analysis of patient data. The discriminatory power of a model is visualizable using box-whisker plots and ROC curves; calibration plots show the match between the predicted chance and the observed frequency of a disease.

[The effect of cancer screening on mortality. The case-control study as evaluation method].

The case-control study is an efficient study design for evaluating the effect of cancer screening. This study method enables calculation of the percentage by which the risk of mortality from cancer decreases in participants in a screening programme if the carcinoma is detected early. Reductions in mortality of 15-65% have been published for participants in a population screening programme for breast, cervical and colorectal cancer.

Age at diagnosis and breast cancer survival in iran.

Background. Tumour characteristics are the most important prognostic factors in breast cancer. Patient-related factors such as young age at diagnosis, obesity, and smoking behaviour may also modify disease outcome.

Pattern of follow-up care and early relapse detection in breast cancer patients.

Routine breast cancer follow-up aims at detecting second primary breast cancers and loco regional recurrences preclinically. We studied breast cancer follow-up practice and mode of relapse detection during the first 5 years of follow-up to determine the efficiency of the follow-up schedule. The Netherlands Cancer Registry provided data of 6,509 women, operated for invasive non-metastatic breast cancer in 2003-2004.

Impact of routine follow-up examinations on life expectancy in ovarian cancer patients: a simulation study.

Objective: The clinical benefit of routine follow-up in patients treated for ovarian cancer is subject to debate. In this study, the magnitude of the potential survival benefit of routine examinations was evaluated by Markov modeling.

Methods: The clinical course of ovarian cancer was simulated using a 4-state nonstationary Markov model.

Impact of high electromagnetic field levels on childhood leukemia incidence.

The increasing exposure to electromagnetic fields (EMFs) has raised concern, as increased exposure may result in an increased risk of childhood leukemia (CL). Besides a short introduction of CL and EMF, our article gives an evaluation of the evidence of a causal relation between EMF and CL by critically appraising the epidemiological and biological evidence. The potential impact is also estimated by the population attributable risk.

[Responsible cancer screening].

In the Netherlands, national screening programs for breast and cervical cancer are operating, whilst that for colorectal cancer is in preparation. In the meantime, experimental studies have been conducted into the effectiveness of prostate and lung cancer screening. Death from these five types of cancer is reduced by these screening investigations.

No supportive evidence for clinical benefit of routine follow-up in ovarian cancer: a Dutch multicenter study.

Introduction: Routine follow-up is standard medical practice in ovarian cancer patients treated with curative intent. However, no strong evidence exists indicating that prognosis is improved. The objective of this study was to evaluate the routine follow-up schedule for ovarian cancer patients regarding the adherence to the Dutch protocol, the detection of recurrences, and the follow-up's impact on overall survival.

Increase in the incidence of gestational trophoblastic disease in The Netherlands.

Objective: The objective of this study is to determine the incidence and time trends of gestational trophoblastic disease (GTD) in The Netherlands using population-based data.

Methods: Data on patients with a pathologically confirmed diagnosis of GTD from 1995 to 2008 were obtained from PALGA, a national archive containing all histopathology reports in The Netherlands. Data on number of deliveries were obtained from the Database of Statistics Netherlands.

Micrometastases or isolated tumor cells and the outcome of breast cancer.

Background: The association of isolated tumor cells and micrometastases in regional lymph nodes with the clinical outcome of breast cancer is unclear.

Methods: We identified all patients in The Netherlands who underwent a sentinel-node biopsy for breast cancer before 2006 and had breast cancer with favorable primary-tumor characteristics and isolated tumor cells or micrometastases in the regional lymph nodes. Patients with node-negative disease were randomly selected from the years 2000 and 2001.

Undertreatment of tracheal carcinoma: multidisciplinary audit of epidemiologic data.

National epidemiologic data were examined to determine the eligibility for curative therapy in tracheal carcinoma. An expert audit of primary tracheal carcinomas registered from 2000 to 2005 with the Netherlands Cancer Registry (NCR) included blinded patient data and radiographic review to assess diagnosis and resectability. Actual treatment was compared with the opinions of a multidisciplinary panel (Radboud panel) and a second reviewer.

Implementation of sentinel node biopsy in breast cancer patients in the Netherlands.

Background: This population-based study describes the implementation of the sentinel node biopsy (SNB) in breast cancer patients in the Netherlands. We examined the extent of use over time of SNB in women who were considered eligible for SNB on the basis of their clinical status.

Methods: The study included a total of 35,465 breast cancer patients who were diagnosed with T1-2 tumours (5.

Local recurrences after different treatment strategies for ductal carcinoma in situ of the breast: a population-based study in the East Netherlands.

Purpose: Outcomes after different treatment strategies for ductal carcinoma in situ (DCIS) of the breast were analyzed for a geographically defined population in the East Netherlands.

Methods And Materials: A total of 798 patients with a first diagnosis of DCIS between January 1989 and December 2003 were included and their medical records were reviewed. Survival rates for ipsilateral recurrences were calculated by the Kaplan-Meier method and a multivariate Cox proportional hazards regression model was used to evaluate the prognostic significance of different variables.

Increased risk of concurrent primary malignancies in patients diagnosed with a primary malignant epithelial ovarian tumor.

Ovarian cancer and second malignant neoplasms are found to occur rather frequently in the same patient. From a clinical perspective, it is important to have quantitative information on concurrent malignancies in the same year of diagnosis of the epithelial ovarian cancer. In this population-based study, we used data from the Netherlands Nationwide Network for Registry of histo- and cytopathology (PALGA) and the Netherlands Cancer Registry (NCR).

Incidence and treatment of tracheal cancer: a nationwide study in the Netherlands.

Background: The aim of this study was to assess the incidence, characteristics, treatment, and survival of patients with tracheal malignancies in the Netherlands.

Methods: All cases of tracheal cancer entered into the database of the Netherlands Cancer Registry in the period 1989-2002 were selected. Data on histological type, age at time of diagnosis, treatment, and survival were analyzed retrospectively.

Primary central nervous system lymphomas: incidence and survival in the Southern and Eastern Netherlands.

Background: An excessive increase in the incidence of primary central nervous system lymphoma (PCNSL) has been reported since the mid-1980s in the U.S. and U.