Publications by authors named "Jory Curry"
Article Synopsis
- Dysfunction in dopamine levels contributes to various psychiatric and neurodegenerative disorders, with the NR4A2 protein linked to conditions like Parkinson's disease and ADHD.
- Researchers used zebrafish mutants to investigate the roles of two nr4a2 paralogs, nr4a2a and nr4a2b, finding distinct effects on dopamine neuron health and behavioral traits related to these conditions.
- The loss of nr4a2a function mirrored Parkinsonian symptoms, while nr4a2b mutants had increased neurotrophic factors but also showed signs of mitochondrial dysfunction and oxidative stress.
Perfluorooctanesulfonic acid (PFOS) has widely been reported to persist in the environment and to elicit neurotoxicological effects in wildlife and humans. Following the restriction of PFOS use, 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) and sodium p-perfluorous nonenoxybenzene sulfonate (OBS) have emerged as novel PFOS alternatives and have been detected in the environment. However, knowledge on the toxicological effects of these alternatives remains scarce.
View Article and Find Full Text PDFMining activities in the Athabasca oil sands region (AOSR) have contributed to an increase of polycyclic aromatic compounds (PACs) locally. However, many PACs found in the AOSR, and the combined effects of PAC mixtures have not been evaluated for genotoxicity in wildlife. Here, we examine whether mutation frequencies in AOSR river otters are correlated to PAC tissue burdens.
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