Electrospinning and mechanical properties of P(TMC-co-LLA) elastomers.

P(TMC-co-LLA) elastomers have shown great potential for various biomaterial and tissue engineering applications. This study systematically investigated properties key to such applications. Three P(TMC-co-LLA) copolymers with 9 to 32 mol% TMC were synthesised and processed into 3D fibrous scaffolds using solution electrospinning.

Tensile properties and in vitro degradation of P(TMC-co-LLA) elastomers.

P(TMC-co-LLA) elastomers have shown great potential for various biomaterials applications. This study investigated properties key to such applications. Six statistical copolymers with 16 to 49 mol% TMC were synthesized and it was found that the LLA sequence length changed from 14 to 3 for the copolymer series while the M[combining macron] decreased from 63 to 31 kg mol with increasing TMC content.

Use of two-step grafting to fabricate dual-functional films and site-specific functionalized scaffolds.

Polycaprolactone (PCL) is a widely utilized bioresorbable polymer in tissue engineering applications. However, the absence of intrinsic functional groups in the polymer backbone necessitates the incorporation of functional chemistries to enable the further addition of bioactive molecules to PCL-based surfaces and scaffolds. The current study aimed to incorporate two different functional groups, amine and carboxylate, first on two-dimensional (2D) spin-coated PCL films and, thereafter, throughout all surfaces within three-dimensional (3D) porous PCL-based scaffolds, produced using the thermally induced phase separation (TIPS) method, but in a spatially separated manner.