Enhancing Ocular Surface in Dry Eye Disease Patients: A Clinical Evaluation of a Topical Formulation Containing Sesquiterpene Lactone Helenalin.

The aim of this work was to assess the tolerability, safety, and efficacy of an ophthalmic topical formulation containing helenalin from and hyaluronic acid 0.4% (HA) in patients with mild-to-moderate Dry Eye Disease (DED) exhibiting positive Matrix Metalloproteinase 9 (MMP-9) test results. Tolerability and safety were evaluated in 24 healthy subjects.

Prevalence and clinical characteristics of neurotrophic keratopathy in hispanic population in northeastern Mexico.

Purpose: To evaluate the prevalence and clinical characteristics of neurotrophic keratopathy (NK) in northeastern Mexico.

Methods: Retrospective cross-sectional study in which NK patients admitted to our ophthalmology clinic between 2015 and 2021 were consecutively enrolled. Data regarding demographics, clinical characteristics, and comorbidities were collected at the time diagnosis of NK was made.

An Oral Polyphenol Formulation to Modulate the Ocular Surface Inflammatory Process and to Improve the Symptomatology Associated with Dry Eye Disease.

Due to their antioxidant, anti-inflammatory, neuroprotective, and anti-angiogenic effects, polyphenols are first-rate candidates to prevent or treat chronic diseases in which oxidative stress-induced inflammation plays a role in disease pathogenesis. Dry eye disease (DED) is a common pathology, on which novel phenolic compound formulations have been tested as an adjuvant therapeutic approach. However, polyphenols are characterized by limited stability and solubility, insolubility in water, very rapid metabolism, and a very short half-life.

Phytochemical Profile and Antioxidant and Antiproliferative Activity of on Pterygium Fibroblasts.

Background: has antioxidant effects that are beneficial for different diseases. We aimed to analyze the antiproliferative activity of in human pterygium fibroblasts (HPFs).

Methods: HPFs were treated for 24 h with 0-1000 g/mL of lyophilized to analyze its effect on cell viability using the CellTiter assay.

COVID-19 and the eye: a review.

Background: To provide a review for general practitioners and medical specialists about the most common eye complaints and ocular manifestations in a COVID-19 patient.

Methods: Reviewed 50 articles referenced in 4 databases from 20 December 2019 to 16 September 2020.

Results: Of the 50 articles reviewed, 26 met the criteria for analysis and were included in the study.

Arresting proliferation improves the cell identity of corneal endothelial cells in the New Zealand rabbit.

Purpose: Corneal endothelium engineering aims to reduce the tissue shortage for corneal grafts. We investigated the impact of mitogenic and resting culture systems on the identity of corneal endothelial cells (CECs) for tissue engineering purposes.

Methods: Rabbit CECs were cultured in growth factor-supplemented media (MitoM) until confluence.